Results 61 to 70 of about 623,870 (286)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Effect of chitosan on buck semen quality and semen plasma metabolites during low-temperature storage

open access: yesFrontiers in Veterinary Science
BackgroundOptimizing buck semen preservation techniques can significantly advance the goat industry. This study aimed to investigate the effects of chitosan on sperm quality and seminal plasma metabolite profiles in bucks during low-temperature storage ...
Meijun Song   +21 more
doaj   +1 more source

Effect of Borassus aethiopum extract as a biological extender on semen characteristics, fertility and hatchability in chickens [PDF]

open access: yesJournal of Agricultural Sciences (Belgrade), 2017
Borassus aethiopum extract as a biological extender was evaluated on semen quality, fertility and hatchability in chickens under conditions of warm preservation at 37oC.
Oluwatoba Adeyina A.   +6 more
doaj   +1 more source

Comparative efficacy of three extenders on quality of boar semen during preservation at 15°C

open access: yesIndian Journal of Animal Sciences, 2020
The present study was designed to compare the efficacy of 3 different extenders for preservation of boar semen at 15°C. Ejaculates (32) were evaluated and extended (1:4) in TRIXcell+, Modena and GEPS extenders and kept for 4 h of holding at 22°C.
T. F. M SANGMA   +5 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Development of a Validation Protocol for Laboratory Personnel Training in Sperm Analysis and Cryopreservation(brief report)

open access: yesMedical Laboratory Journal, 2022
Background and objectives: Semen cryopreservation is widely used in assisted reproduction techniques, and reliable semen analysis is essential to define the clinical practice. However, many parameters used for semen evaluation have high variability among
Karolyn Sassi Ogliari   +7 more
doaj  

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

open access: yesAging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Impact of semen extenders, storage duration, and insemination timing on semen quality and reproductive performance in Palestinian Assaf sheep [PDF]

open access: yesVeterinary World
Background and Aim: Artificial insemination (AI) is a critical technique in sheep breeding programs, yet its success is influenced by factors such as semen quality, storage conditions, and insemination timing. This study examines the effects of different
Wael Halawa   +6 more
doaj   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen   +5 more
wiley   +1 more source

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