Results 71 to 80 of about 739,005 (270)

Non-linear diffusive shock acceleration with free escape boundary

, 2010
We present here a semi-analytical solution of the problem of particle acceleration at non-linear shock waves with a free escape boundary at some location upstream.
Amato, E., Blasi, P., Caprioli, D.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Regular Oscillation Sub-spectrum of Rapidly Rotating Stars

, 2012
We present an asymptotic theory that describes regular frequency spacings of pressure modes in rapidly rotating stars. We use an asymptotic method based on an approximate solution of the pressure wave equation constructed from a stable periodic solution ...
B. Georgeot, Berry, Blümel, Bohigas, D. R. Reese, F. Lignières, García Hernández, Koch, Kogelnik, Lignières, Lignières, Lignières, Lignières, M. Pasek, Mantegazza, Miller, Monnier, Pasek, Percival, Reese, Reese, Reese, Reese, Schomerus, Tassoul, Tureci, Vagov, Vandakurov, Zalipaev   +28 more
core   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Semi-analytical solutions of the Schnakenberg model of a reaction-diffusion cell with feedback

Results in Physics, 2018
This paper considers the application of a semi-analytical method to the Schnakenberg model of a reaction-diffusion cell. The semi-analytical method is based on the Galerkin method which approximates the original governing partial differential equations ...
K.S. Al Noufaey
doaj   +1 more source

Semi-analytical method for solving stresses in slope under general loading conditions

Applied Rheology, 2023
Assessing the stress distribution within the slope in geotechnical engineering is critical. Despite the widely available numerical methods, no analytical solutions are available for determining the stress distribution within a slope under general loading
Wu Ping, Sun Xuejun, Zhu Dayong Zhu
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Through-thickness damage distribution in sheet bending employing the workability diagram

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение
A semi-analytical solution is constructed to determine the through-thickness distribution of the average stress triaxiality parameter included in the ductile fracture criterion in sheet bending under the action of a bending moment and tensile force.
E. A. Lyamina
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Analytical frequency-domain solution for Euler-Bernoulli frames with semi-rigid connections

Forces in Mechanics
This paper presents a novel method for analyzing the dynamic response of plane Euler-Bernoulli frames with semi-rigid connections subjected to arbitrary external loads and bending moments.
Jorge Eliecer Ballesteros Ortega, Cristian Posso, Juan Camilo Molina-Villegas   +2 more
doaj   +1 more source