Results 211 to 220 of about 5,219,531 (278)

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

A Multimodal Therapist-Supervised Robotic Gait-Training Platform with Phase-Synchronized Infrared Thermal Biofeedback: A Concept-Level Technical and Translational Healthcare Framework. [PDF]

Healthcare (Basel)
Calabrò RS, Crespantini A, Calderone A, Troncone S.   +3 more
europepmc   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Multiple aspartic proteases process PE and PPE proteins on the mycobacterial surface of pathogenic mycobacteria. [PDF]

J Biol Chem
Meijers AS, Gallant JL, Speer A, Maaskant J, Hietamäki S, Ummels R, Paulußen FM, Grossmann TN, Pham TV, Piersma SR, Jiménez CR, Nejentsev S, Bitter W, Kuijl CP.   +13 more
europepmc   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

A high-resolution electrostatically actuated MEMS Fabry-Pérot tunable filter for LWIR imaging and sensing applications. [PDF]

Microsyst Nanoeng
Xu T, Yang H, Hou H, Xu S, Yao Z, Wang P, Li L, Zhang K, Zhao J.   +8 more
europepmc   +1 more source

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source

Smart delivery of herbicide for safe and effective control of Egyptian broomrape parasitizing Indian mustard. [PDF]

Sci Rep
Jat RS, Agrawal A, Kala S, Choudhary RL, Singh HV, Kumar J, Singh VV.   +6 more
europepmc   +1 more source

Surfing Across Life Domains: A Qualitative Study on the Role of Leisure Activities in Occupational Well-Being. [PDF]

Int J Environ Res Public Health
Gemmano CG, Petruzzelli MP, Manuti A.
europepmc   +1 more source

The Isolation and Characterization of ACE Inhibitory Peptides from <i>Pelodiscus sinensis</i> Wiegmann Meat and Their Effects on the Viability of HSC-T6 Cells. [PDF]

Foods
Jiao F, Sun X, Zhang T, Li X, Zheng G, Que L, Liang Y, Liao P.   +7 more
europepmc   +1 more source