Results 111 to 120 of about 458,190 (303)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Role of Caspase -3 and Total Antioxidant Capacity (TAC) in Idiopathic Infertile Male

Diyala Journal of Medicine, 2018
Background: Sperm differentiation during spermatogenesis is highly regulated by different caspases and oxidant-antioxidant mechanisms.    Objective: To assess the levels of the caspase -3 and total antioxidant capacity (TAC) in seminal plasma and ...
Madha Mohammed Sheet Saleh, Estabraq Abdulrasool Al -Wasiti, Adnan Nafil Muslim   +2 more
doaj   +2 more sources

The Role of Exercise to Reduce the Impact of Diabetes in the Seminal Quality: A Systematic Review. [PDF]

Medicina (Kaunas), 2021
Lavín-Pérez AM, Collado-Mateo D, Villafaina S, Calle-Guisado V.   +3 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Study of seminal infection among an infertile male population in Qom, Iran, and its effect on sperm quality

Iranian Journal of Microbiology, 2018
Background and Objectives: There are very few analysis tools to examine seminal fluid specimens, so bacterial infections on male infertility has always been the subject of discussion.
Katayon Berjis, Mahdieh Ghiasi, Sareh Sangy   +2 more
doaj  

Evaluating the Effects of Heavy Metals on Seminal Fluid Anti Oxidants Status and Semen Parameters among Males with Infertility at Tertiary Health Centre in Nigeria

Advances in Human Biology
Introduction: There are evidences of a reduction in male fertility potential globally. This, coupled with the limitation of the gold standard investigative tool of male infertility, has become necessary that focus should be on elucidating the ...
Waliu Olatunbosun Oladosu, Oluwafemi Ademola Lawani, Rasaki Adewale Oyewo, Kazeem Adebayo Oderinu, Olanrewaju Saheed Jimoh, Babatunde Olarenwaju Motayo, Oluwamayowa Hidaayah Jimoh AbdulGhaffaar   +6 more
doaj   +1 more source

Collection and freezing of equine epididymal spermatozoa [PDF]

, 2014
The epididymis and vas deferens store an important number of fertile spermatozoa called the extragonadal sperm reserves. These stored spermatozoa can be collected in an ultimate attempt to preserve viable spermatozoa of a critically ill or dying stallion.
Govaere, Jan, Hoogewijs, Maarten, Leemans, Bart, Roels, Kim, Van Soom, Ann, Ververs, Cyrillus   +5 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The anglocentric tendency in the history of information engineering [PDF]

, 2017
This paper examines the anglocentric nature of much writing on the history of technology, taking as an example important research results from the first half of the last century published in German and Russian in the field of information engineering. By ‘
Bissell, Christopher
core