Results 111 to 120 of about 42,857 (194)

Pubertal Dynamics of Sertoli and Leydig Cell Dysfunction in Klinefelter Syndrome

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Context Klinefelter syndrome (KS), defined by a 47, XXY karyotype, is commonly associated with progressive testicular failure. The precise timing of Sertoli and Leydig cell dysfunction during puberty remains unclear. Objective To determine the onset and progression of testicular insufficiency during puberty in KS, and to assess whether ...
Tredez Axelle   +9 more
wiley   +1 more source

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

open access: yesCell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang   +8 more
wiley   +1 more source

Wt1 Is Required for the Regression of Müllerian Ducts in Male Mice by Inducing Wif1 and Osx Expression

open access: yesCell Proliferation, EarlyView.
Wt1 expressed in the MD mesenchyme promotes MD regression by inducing Wif1 and Osx transcription. In male mice, mesenchyme‐specific inactivation of Wt1 results in MD retention. ABSTRACT In mammals, Müllerian ducts (MDs) are the precursors of the female reproductive tract which regress in males during embryonic development.
Min Chen   +12 more
wiley   +1 more source

Testicular torsion in foals and stallions

open access: yesEquine Veterinary Education, EarlyView.
Summary Testicular torsion is a rare condition in horses characterised by a change in the position of the testis due to the testicular mesentery twisting around its own axis; it can occur both when the testis is still in the abdominal cavity and when it has descended into the scrotum.
C. P. Bartmann
wiley   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

open access: yesThe FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari   +7 more
wiley   +1 more source

METHOTREXATE LEVELS IN THE INTERSTITIAL SPACE AND SEMINIFEROUS TUBULE OF RAT TESTIS

open access: yes, 1982
The ability of methotrexate (MTX) to pass from the blood into the interstitial space and seminiferous tubule of the rat was investigated using testicular micropuncture.
Riccardi, Riccardo
core  

Effect of royal jelly as supplementation in feed on sperm progressive motility and histology of testis for rabbits [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST)
Royal jelly (RJ) was applied as a supplement in feed to examine its impact on rabbit buck fertility. The aims were to evaluate the effect of RJ on sperm progressive motility and on histology of testis in rabbits.
Fathin Athirah Mohd Sabri   +3 more
doaj  

Berberine is sufficient to restore the destroyed seminiferous tubule structure and hypospermatogenesis in diabetes mellitus. [PDF]

open access: yesClin Transl Med, 2020
Gao X   +13 more
europepmc   +1 more source

Gonadal development in scorpion mud‐turtles, Kinosternon scorpioides, in a controlled environment

open access: yesThe Anatomical Record, Volume 309, Issue 11, Page 3455-3466, November 2026.
Stage 20 was identified as the critical point for gonadal differentiation in Kinosternon scorpioides, providing key insights into sex determination. These findings enhance conservation strategies by supporting reproductive management and population viability in both in situ and ex situ programs. Abstract Research on gonadal development including sexual
Brenda Braga   +4 more
wiley   +1 more source

Design and Fabrication of 3D-Printed Seminiferous Tubule-Like Constructs Based on Polycaprolactone–Decellularized Extracellular Matrix and Evaluation of Testicular Cell Viability

open access: yes
Male infertility is frequently associated with damage to the seminiferous tubules. This project aims to design and fabricate 3D-printed seminiferous tubule-like constructs using a polycaprolactone–decellularized extracellular matrix composite and to ...
mehrnoushmalekzadeh
core   +1 more source

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