Results 81 to 90 of about 42,857 (194)

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Gradual Thickening of the Peritubular Lamina Propria in Healthy Boar Seminiferous Tubules Due to Cryptorchidism: Increased Immunoexpression of Diverse Proteins in Sertoli and Myoid Cells

Animals
In testicular pathology, the accumulation of extracellular matrix and thickening of the peritubular lamina propria are associated with altered spermatogenesis.
Vicente Seco-Rovira, Jesús Martínez-Hernández, Laís Freire-Brito, Ester Beltrán-Frutos, Juan Francisco Madrid, Luis Miguel Pastor   +5 more
doaj   +1 more source

Characterization of stem cells associated with seminiferous tubule of adult rat testis for their potential to form Leydig cells

Stem Cell Research, 2019
Adult testicular Leydig cells arise from stem cells in the neonatal and adult testis. The nature of these stem Leydig cells (SLCs) have not been well characterized.
Xiaoju Guan, Panpan Chen, Xingxing Zhao, Xinrui Hao, Fenfen Chen, Minpeng Ji, Xin Wen, Han Lin, Leping Ye, Haolin Chen   +9 more
doaj   +1 more source

In Situ Expression of miR‐371a‐3p and miR‐373‐3p in Testicular Germ Cell Tumours and Detection in Serum

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCTs) are the most common type of tumour diagnosed in young men, and reliable non‐invasive biomarkers are crucial for clinical management. MicroRNAs (miRNAs) from the miR‐371–373 cluster have recently been identified as novel and more sensitive serum biomarkers than the conventional protein‐based ...
Nina Mørup, Merve Tatli, Thomas Wagner, Helle Margit Albrechtsen, Gülizar Saritas, Gedske Daugaard, Sofia B. Winge, Kristian Almstrup   +7 more
wiley   +1 more source

Cyclic AMP production in isolated rat seminiferous tubule cell preparations: a potential in vitro assay for follicle stimulating hormone

, 1975
A simple procedure for the isolation of rat seminiferous tubule cell preparations free of Leydig cells is described. Both ovine and human FSH stimulated cyclic AMP accumulation. in proportion to the concentration of the hormones.
Jagannadha Rao, A., Ramachandran, J.
core   +1 more source

Seminiferous tubule transfection in vitro to define post-meiotic gene regulation

Reproductive Biology and Endocrinology, 2009
Background Post-meiotically expressed genes in the testis are essential for the proper progression of spermatogenesis, and yet, aside from the construction of individual transgenic mice using specific promoters to drive reporter plasmids, there are only ...
Kirchhoff Christiane, Danner Sandra, Ivell Richard   +2 more
doaj   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Claudin-11 and connexin-43 display altered spatial patterns of organization in men with primary seminiferous tubule failure compared with controls

, 2013
OBJECTIVE: To assess the spatial organization of two proteins involved in the Sertoli cell junctional complex in men with primary seminiferous tubule failure. DESIGN: Retrospective study. SETTING: Medical research institute. PATIENT(S): Sixteen men total,
Haverfield, J., McLachlan, R., O'Bryan, M., Stanton, P., Meachem, S.   +4 more
core   +1 more source

Age related histological and histochemical studies on the testis of Aseel and Vanaraja breeds of poultry

Indian Journal of Animal Sciences, 2014
Birds (10) of 2 age group, viz. 5 months (grower) and 13 months (adult) of Aseel and Vanaraja breeds of poultry were used. The thickness of tunica albuginea, maximum and minimum diameter of seminiferous tubules, diameter of primary spermatocytes and ...
S K DESHMUKH, S P INGOLE, D CHAURASIA, S K KARMORE, B SINHA   +4 more
doaj   +1 more source

Diacerein Disrupts Testicular Homeostasis: The Essential Role of Basal Cytokines in Maintaining Sertoli Cell Integrity and the Immune Microenvironment

Andrology, EarlyView.
ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus, André Acácio Souza da Silva, Olumide Stephen Akinsomisoye, Erick J. R. Silva, Paulo Sérgio Cerri, Salmo Azambuja de Oliveira, Estela Sasso‐Cerri   +6 more
wiley   +1 more source