Results 51 to 60 of about 5,696,429 (330)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The colonization of maize seedling roots and rhizosphere by Fusarium spp. in Mississippi in two soil types under conventional tillage and notillage systems [PDF]

, 2000
De 1995 à 1997, le maïs hybride Pioneer 3167 a été semé annuellement à quatre dates dans deux types de sol du Mississippi et échantillonné hebdomadairement de une à quatre semaines après le semis.
Ingram, D., Soonthornpoct, P., Trevathan, L.E.   +2 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Résilience de la lentille au changement climatique au Maroc : principales réalisations en amélioration génétique, biotechnologie et gestion des cultures

African and Mediterranean Agricultural Journal - Al Awamia
Au Maroc, la lentille est cultivée dans des conditions pluviales et sa productivité est fortement influencée par les aléas climatiques, notamment la quantité et la distribution des précipitations, ainsi que les hautes températures.
Abdelmonim Zeroual, Mohammed Mitache, Aziz Baidani, Hanane Ouhemi, Sanae Krimi Bencheqroun, Fatima Zahra Ibn El Mokhtar, Rachid Mentag, Nadia Benbrahim, Omar Idrissi   +8 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Contribution de la recherche agricole pour une meilleure résilience de l’agriculture marocaine

African and Mediterranean Agricultural Journal - Al Awamia
L’agriculture joue un rôle socio-économique important au Maroc. Elle représente 13 % du Produit National Brut du pays et engage environ 46 % de la population.
Faouzi Bekkaoui, Mohammed Sadiki, Imane Thami Alami   +2 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Algebraic Invariants for Inferring 4-leaf Semi-Directed Phylogenetic Networks [PDF]

, 2023
Samuel Martin, Vincent Moulton, Richard M. Leggett, Richard M. Leggett   +3 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Désherbage chimique et gestion de l'enherbement du cotonnier au Nord-Cameroun [PDF]

, 2009
International audienceL'objectif de cette étude menée entre 2005 et 2007, était de faire un diagnostic des pratiques paysannes de gestion de l'enherbement dans deux terroirs du Nord-Cameroun (Mafa kilda et Mowo), et de tester différentes techniques de ...
Marnotte, Pascal, Olina Bassala, Jean-Paul, Wirnkar Lendzemo, Vénasius   +2 more
core   +1 more source