Results 31 to 40 of about 10,314,776 (281)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Efficacité de quelques herbicides des céréales dans une culture du blé tendre conduite en semis direct

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2016
Dans l’intérêt d’évaluer l’efficacité de 11 herbicides des céréales dans une culture du blé tendre en semis direct, deux essais ont été conduits dans la région de la Chaouia durant la campagne agricole 2014-2015.
Badr HAJJAJ, Mohamed BOUHACHE, Rachid MRABET, Abdelkader TALEB, Ahmed DOUAIK   +4 more
doaj   +2 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Efficacité de quelques séquences d'herbicides contre les mauvaises herbes du pois chiche et de la féverole conduits en semis direct

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2016
Dans le but d’évaluer l’efficacité de différentes séquences d’herbicides de pré levée et post levée sur les mauvaises herbes associées au pois chiche et à la féverole en semis direct et leur impact sur le rendement grain, 18 séquences d’herbicides ont ...
Badr HAJJAJ, Mohamed BOUHACHE, Rachid MRABET, Abdelkader TALEB, Ahmed DOUAIK   +4 more
doaj   +2 more sources

Freins à l’adoption des pratiques agroécologiques : enseignements d’une enquête territoriale dans le projet de territoire pour gestion de l’eau (PTGE)

Sciences, Eaux & Territoires
Dans le territoire du bassin versant du Midour, une enquête menée auprès de 124 exploitations agricoles des Landes et du Gers met en lumière les évolutions des pratiques agroécologiques et les freins qui limitent leur adoption.
Victor TRANCHANT, Juliette GOURAULT
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Enquête semis direct sous couvert végétal transition agronomique et évolution des problèmes malherbologiques

, 2020
article technique à destination des professionnels.National audienceUne équipe de l’Inrae de Dijon (UMR Agroécologie) a enquêté sur la pratique du semis direct sous couvert et ses effetssur l’évolution de la flore adventice.
Dessaint, Fabrice, Chauvel, Bruno, Derrouch, Damien, Felten, Emeline   +3 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source