Results 201 to 210 of about 3,084,067 (325)

Linking cortical structure and delirium in the elderly: insights from cohort study and shared genetic risk analysis. [PDF]

open access: yesJ Transl Med
Chen Y   +14 more
europepmc   +1 more source

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

open access: yesAdvanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang   +9 more
wiley   +1 more source

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

open access: yesAdvanced Science, EarlyView.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu   +23 more
wiley   +1 more source

From Design to Prototype: High‐Sensitivity Tri‐Mode Operation Photodetectors Based on 1T‐2H Hybrid MoS2

open access: yesAdvanced Science, EarlyView.
This work demonstrates a phase‐engineered MoS2 photodetector that dynamically switches among photocapacitive (PCC), photovoltaic (PV), and photoconductive (PC) modes. By transforming the traditionally parasitic capacitance into an active signal source, the device achieves self‐powered, high‐sensitivity detection with a fast response of 19.2 ms, and a ...
Xinyu Li   +16 more
wiley   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu   +15 more
wiley   +1 more source

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