Results 151 to 160 of about 12,101,411 (341)

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

Redox Biology, 2018
Cellular senescence is characterised by the irreversible arrest of proliferation, a pro-inflammatory secretory phenotype and evasion of programmed cell death mechanisms.
Shashank Masaldan, Sharnel A.S. Clatworthy, Cristina Gamell, Peter M. Meggyesy, Antonia-Tonia Rigopoulos, Sue Haupt, Ygal Haupt, Delphine Denoyer, Paul A. Adlard, Ashley I. Bush, Michael A. Cater   +10 more
doaj   +1 more source

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

Aging Cell, 2019
Adipose tissue inflammation and dysfunction are associated with obesity‐related insulin resistance and diabetes, but mechanisms underlying this relationship are unclear. Although senescent cells accumulate in adipose tissue of obese humans and rodents, a
Allyson K. Palmer, Ming Xu, Yi Zhu, T. Pirtskhalava, Megan M. Weivoda, Christine M. Hachfeld, L. Prata, T. V. van Dijk, E. Verkade, Grace Casaclang-Verzosa, Kurt O. Johnson, H. Čubro, E. Doornebal, M. Ogrodnik, D. Jurk, M. Jensen, E. Chini, Jordan D. Miller, A. Matveyenko, Michael B. Stout, M. Schafer, T. White, L. Hickson, M. Demaria, V. Garovic, J. Grande, E. Arriaga, F. Kuipers, T. von Zglinicki, N. LeBrasseur, J. Campisi, T. Tchkonia, J. Kirkland   +32 more
semanticscholar   +1 more source

Senescent cells in the development of cardiometabolic disease [PDF]

, 2019
Purpose of review Senescent cells have recently been identified as key players in the development of metabolic dysfunction. In this review, we will highlight recent developments in this field and discuss the concept of targeting these cells to prevent or
Jonker, Johan W.; id_orcid, van de Sluis, Bart; id_orcid, Sturmlechner, Ines, Postmus, Andrea C., Kruit, Janine K., van Deursen, Jan M., Kruit, Janine K.; id_orcid, Jonker, Johan W., van de Sluis, Bart, Sturmlechner, Ines; id_orcid, Postmus, Andrea C.; id_orcid   +10 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Different transcriptional profiling between senescent and non-senescent human coronary artery endothelial cells (HCAECs) by Omeprazole and Lansoprazole treatment [PDF]

, 2017
Recent evidence suggests that high dose and/or long term use of proton pump inhibitors (PPIs) may increase the risk of adverse cardiovascular events in older patients, but mechanisms underlying these detrimental effects are not known. Taking into account
Piacenza, Francesco, MAGGIO, Marcello Giuseppe, Lattanzio, Fabrizia, Provinciali, Mauro, Maggio M. G., Costarelli L., Corsonello, Andrea, Corsonello A., Giacconi R., Malavolta, Marco, Malavolta M., Basso A., Giacconi, Robertina, Costarelli, Laura, Piacenza F., Basso, Andrea, Provinciali M., Lattanzio F.   +17 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Cell cycle arrest is not senescence

Aging, 2011
DNA damaging agents and radiation, cytotoxins and anti-cancer drugs, telomere erosion and cytokines, culture shock and mitogenic stimuli, oncogenes and tumor suppressors can induce both cell cycle arrest and cellular senescence. Due to this semi-coincidence, senescence is confused with cell cycle arrest, or even more misleadingly, with growth ...
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source