Results 181 to 190 of about 1,556 (255)

[Age-dependent oxidative stress: toward an irreversible failure in endothelial maintenance]. [PDF]

open access: yesMed Sci (Paris), 2010
Thorin-Trescases N   +5 more
europepmc   +1 more source

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

open access: yesAdvanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang   +10 more
wiley   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

open access: yesAdvanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long   +12 more
wiley   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

open access: yesAdvanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui   +5 more
wiley   +1 more source

EQUILÍBRIO ESTÁTICO E DINÂMICO EM INDIVÍDUOS SENESCENTES E O ÍNDICE DE MASSA CORPORAL

open access: yes, 2008
O estudo objetivou analisar o equilíbrio estático e o dinâmico em indivíduos senescentes e verificar sua associação com a idade e com o Índice de Massa Corporal (IMC).
José Rubens Rebelatto   +3 more
core  

Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. [PDF]

open access: yesInt J Cosmet Sci
Zonari A   +10 more
europepmc   +1 more source

In Situ Programmable Modulation of Hydrogel Stiffness for Stage‐Adaptive Bone Regeneration

open access: yesAdvanced Science, EarlyView.
Near‐infrared (NIR) irradiation triggers Ca2+ release from thermoresponsive nanocarriers, enabling in situ stiffening of an adaptive hydrogel from a soft to a stiff state, thereby sequentially supporting mesenchymal stromal cell stemness and osteogenic differentiation for stage‐adaptive bone regeneration.
Yuxin Yang   +5 more
wiley   +1 more source

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