Results 121 to 130 of about 296 (224)

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Pré-senescentes, uma nova realidade : que desafios para o serviço social?

, 1994
O presente artigo constituí uma breve síntese de uma pesquisa, esta traduz-se na primeira abordagem da prática profissional dos Assistentes Sociais com indivíduos pré-senescentes'. Estes indivíduos constituem interesse de estudo devido às vulnerabilidades a que ficam sujeitos, decorrentes das actuais mutações político e sócio-económicas, nomeadamente a
Ferreira, Conceição, Cruz, Cristina, Godinho, Maria Clara, Ramos, Maria de Fátima   +3 more
openaire   +1 more source

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Avaliação da fenologia das cultivares de macieira Imperatriz, Imperatriz Gala e Fuji em pomar em Bom Retiro – SC

Biotemas, 2007
O trabalho foi realizado em um pomar localizado em Bom Retiro, Santa Catarina. O objetivo foi realizar um estudo fenológico das cultivares Imperatriz, Imperatriz Gala e Fuji, produzidas no pomar e suas relações com a condução do pomar, polinização e ...
Maria Tereza Bolzon Soster, Ana Frederica Latorre   +1 more
doaj  

Análise da qualidade muscular e funcionalidade de ratas senescentes após treinamento combinado

, 2022
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
openaire   +1 more source

Mecanismo biológicos involucrados en el reconocimiento y la fagocitosis de los eritrocitos senescentes

, 2013
Los glóbulos rojos (GRs) constituyen un interesante modelo para estudiar el envejecimiento celular debido a la facilidad de obtención de la muestra, su constante remoción y la carencia de núcleo y otras organelas subcelulares. El término “senescencia” se utiliza para los hematíes que muestran la mayor cantidad de cambios dependientes del tiempo y ...
openaire   +2 more sources

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Estudio químico de los compuestos bioactivos de hojas senescentes de Croton funckianus (Euphorbiaceae)

, 2010
El extracto etanólico de hojas senescentes frescas de Croton funckianus se sometió a partición líquido-líquido con disolventes de diferente polaridad. Los ensayos de actividad larvicida frente a larvas de tercer estadío de Culex quinquefasciatus, mostraron que las fracciones separadas en éter de petróleo (F2), acetato de isopropilo (F5) y butanol (F7 ...
openaire   +2 more sources