Results 151 to 160 of about 1,556 (255)

Estado nutricional del paciente geriátrico hospitalizado.

Gaceta Médica Espirituana, 2012
La edad se acompaña de una serie de circunstancias fisiológicas, económicas y sociales que contribuyen a afectar de una manera adversa el estado nutricional de la población anciana, la hospitalización es una de ellas. El objetivo de la investigación fue
Tamara Álvarez Gómez, Jorge Enrique Izquierdo Paz, Marisel de la C. Valdes Mijares, Cristina Cabrera Cabrera, Ricardo E. Amurrio Flores, Edwin Giovany Ortiz Rojas   +5 more
doaj  

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

Efecto de resolvina D1 sobre la secreción de citoquinas y colágeno en miofibroblastos cardíacos senescentes inducidos por TGF-β1

El envejecimiento es uno de los factores más preponderantes para el desarrollo de enfermedades cardiovasculares (ECV). Uno de los sellos característicos del envejecimiento es la senescencia celular.
Espinoza Pérez, Claudio Andrés
core   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

COMPOSIÇÃO QUÍMICA E ATIVIDADE ANTIMICROBIANA DO ÓLEO ESSENCIAL DAS FOLHAS SENESCENTES DE CÚRCUMA LONGA L. [PDF]

, 2018
Curcuma longa L. (turmeric) leaf is a residual product during root harvesting operations. Traditionally, these leaves, are widely used in cooking, are aromatic and contain essential oil.
FABRI, Eliane Gomes, DUARTE, Marta Cristina Teixeira, AZEVEDO FILHO, Joaquim Adelino, FACANALI, Roselaine, TERAMOTO, Juliana Rolim Salomé   +4 more
core  

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Diseño racional y caracterización de nanodispositivos de sílice mesoporosa para liberación controlada en células senescentes

, 2017
[ES] La senescencia celular es un estado que se caracteriza por un arresto del ciclo celular permanente y un fenotipo hipersecretor asociado. Originalmente se atribuyó al envejecimiento celular, pero hoy se sabe que puede ser causado por otros.
Blasco Carrasco, Jordi
core  

Comportamiento de la violencia intrafamiliar en el adulto mayor

Archivo Médico de Camagüey, 2009
Fundamento: la prevención de la violencia en su marco general y familiar es una prioridad que exige un conocimiento exhaustivo de su magnitud; ya que es observada como un asunto de salud pública por su impacto negativo en la sociedad.
Lourdes Docampo Santaló, Rita Barreto Lacaba, Caridad Santana Serrano   +2 more
doaj  

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source