Results 121 to 130 of about 1,556 (255)

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Diabetes en el senescente: resumen

Medwave, 2001
Manuel García De los Ríos, Pilar Durruty   +1 more
openaire   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Traslación nutrimental e incremento medio anual en teca (Tectona grandis L.f.), en Tabasco, México

Colombia Forestal
La traslación nutrimental es la cantidad de nutrientes que son movilizados desde las hojas senescentes a otros tejidos de los árboles. El objetivo de este estudio fue estimar la traslación nutrimental y el incremento medio anual (IMA) en diámetro, altura
José Jesús Obrador Olán, Alberto Cordova Sanchez, Eustolia García López, Mepivoseth Castelán Estrada, David Jesús Palma López, Gilverto Villanueva López, Guillermina Pascual Cordova, José Francisco Juarez López   +7 more
doaj   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

Relaciones entre los patrones de descomposición de las hojas senescentes y los atributos de las plantas ene ecosistemas áridos del norte de la Patagonia

, 2016
La descomposición de las hojas senescentes es un proceso relevante para el funcionamiento de los ecosistemas, ya que regula la disponibilidad de nutrientes en el suelo para el crecimiento de las plantas.
Carrera, Analía Lorena, Bertiller, Monica Beatriz, Bar Lamas, Marlene Ivonne   +2 more
core   +1 more source

Comparison of senescence progression in mesenchymal cells from human umbilical cord walls measured by immunofluorescence and flow cytometry of p16 and p21. [PDF]

Einstein (Sao Paulo), 2020
Silva AD, Piccinato CA, Sardinha LR, Sardinha LR, Aloia TPA, Goldberg AC.   +5 more
europepmc   +1 more source

Diabetes en el senescente: tratamiento

Medwave, 2001
Manuel García De los Ríos, Pilar Durruty   +1 more
openaire   +1 more source

Papel homeostático e inflamatorio de neutrófilos senescentes

, 2018
Los neutrófilos son los leucocitos más abundantes en la circulación humana y representan la primera barrera de defensa contra microorganismos patógenos. Su número en circulación muestra un comportamiento temporalmente oscilatorio, con una periodicidad circadiana.
openaire   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source