Results 51 to 60 of about 1,558 (255)

Leaf senescence of common bean plants as affected by soil phosphorus supply Senescência foliar do feijoeiro afetada pelo suprimento de fósforo no solo

Revista Brasileira de Ciência do Solo, 2007
Responses of leaf senescence to P supply could constitute adaptive mechanisms for plant growth under P-limiting conditions. The aim of this study was to evaluate the effects of soil P supply on leaf senescence of common bean (Phaseolus vulgaris L ...
Adelson Paulo Araújo, Flavio Yuudi Kubota, Marcelo Grandi Teixeira   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Efecto de factores secretados por las células senescentes en la agregación plaquetaria [PDF]

, 2016
63 p.Alteraciones de la agregación plaquetaria son frecuentemente observadas en pacientes con cáncer y están asociadas a un mal pronóstico. Se considera que las células tumorales afectan la activación plaquetaria a través de varios mecanismos (1).
Quintanilla Medina, Ricardo Joel, Brown, Nelson (Prof. Guía), Moore Carrasco, Rodrigo (Prof. Informante)   +2 more
core  

Enraizamento de estacas e produção de Euryops chrysanthemoides (DC.) B. Nord. em vaso

Ornamental Horticulture, 2016
Os experimentos foram conduzidos no Setor de Floricultura da UFSM no período de agosto de 2013 amaio de 2014, em duas fases experimentais. O primeiro experimento teve o objetivo de verificar o enraizamento de estacas de Euryops chrysanthemoides em ...
Janine Farias Menegaes, Fernanda Alice Antonello Londero Backes, Rogério Antonio Bellé, Túlio Eduardo de Seixas Peres   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Liberación de sustancias en células senescentes [PDF]

, 2012
La invención trata de nanodispositivos para la liberación controlada de sustancias que comprenden un soporte recubierto por oligosacáridos, donde dichos oligosacáridos comprenden al menos 3 unidades de monosacáridos, y donde al menos uno de los ...
Murguía, José Ramón, Marcos, M. Dolores, Sancenón, Félix, Martínez Máñez, Ramón, Moreno Torres, Marta, Perona Abellón, Rosario, Mondragón Martínez, Laura, Manguan-García, Cristina, Agostini, Alessandro, Soto, Joan   +9 more
core