Results 41 to 50 of about 1,556 (255)
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Revista de Pesquisa Cuidado é Fundamental Online, 2021 Objetivo: analisar as produções científicas acerca da participação dos idosos integrantes de Centros de Convivência para Idosos e a influência destes na qualidade de vida dos participantes.
Anne Carolinne Marie dos Santos Gomes +5 more
doaj +4 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Remoción mecánica del material senescente para la recuperación de pasturas
Agronomía Mesoamericana, 2019 Introducción. La acumulación de material senescente en pasturas tropicales es resultado de la alta producción de biomasa y bajo nivel de aprovechamiento en pastoreo. La remoción de senescencia en pasturas permite que el ganado acceda a estratos bajos durante el pastoreo, lo que genera un rebrote con mayor concentración de nutrientes. Objetivo.
Rodolfo WingChing-Jones +1 more
openaire +6 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Resolvina D1 y navitoclax disminuyen el número de miofibroblastos cardiacos senescentes inducidos por TGF-β1 [PDF]
, 2022 La búsqueda de nuevas terapias relacionadas a las enfermedades cardiovasculares ha cobrado gran relevancia dadas las alarmantes cifras respecto al porcentaje en el padecimiento de estas afecciones a nivel mundial.
Ortega Bustos, Juan Vicente
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Gaceta Médica Espirituana, 2017 Introducción: El abuso hacia los adultos mayores es un problema social y sanitario en aumento debido al incremento de: la expectativa de vida, los avances terapéuticos que prolongan la supervivencia y la pérdida de valores familiares tradicionales ...
Tamara Álvarez Gómez
doaj