Results 131 to 140 of about 294 (222)

Mecanismo biológicos involucrados en el reconocimiento y la fagocitosis de los eritrocitos senescentes

, 2013
Los glóbulos rojos (GRs) constituyen un interesante modelo para estudiar el envejecimiento celular debido a la facilidad de obtención de la muestra, su constante remoción y la carencia de núcleo y otras organelas subcelulares. El término “senescencia” se utiliza para los hematíes que muestran la mayor cantidad de cambios dependientes del tiempo y ...
openaire   +2 more sources

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Influencia de la Casa de Abuelos sobre el adulto mayor Influence of the Grandparents' house on the elderly

Medisan, 2010
Se realizó una investigación prospectiva de 27 ancianos que acudían diariamente a la Casa de Abuelos del municipio de San Luis en la provincia de Santiago de Cuba, los cuales intervinieron entusiastamente en ejercicios físicos, charlas educativas y ...
Yolaida Ortega Márquez
doaj  

O senescente nipônico e o voluntariado [PDF]

, 2019
openaire   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

[The role of immunosenescence and inflammaging in aging-associated diseases]. [PDF]

Rev Med Inst Mex Seguro Soc
García-de la Rosa MT, Wong-Baeza I, Arriaga-Pizano LA.   +2 more
europepmc   +1 more source

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

Advanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu, Jingyu Yu, Suhui Wang, Xinghong Hu, Lele Jin, Nan Wu, Yuhan Ni, Xueying Zhang, Chengling Zhao, Jihong Zhou, Yong Zhang, Baofa Sun, Hongxing Zhang, Chunfu Zheng, Song Guo Zheng, Wei Li, Xinxing Zhu   +16 more
wiley   +1 more source

Perspectivas de uso de células-tronco em cirurgia vascular. [PDF]

J Vasc Bras, 2016
Bertanha M.
europepmc   +1 more source

Diabetes en el senescente: definiciones, patogénesis, clínica y control

Medwave, 2001
Manuel García De los Ríos, Pilar Durruty   +1 more
openaire   +1 more source