Results 41 to 50 of about 293 (222)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Hernia interna de divertículo de Meckel como causa de obstrucción intestinal en un senescente [PDF]

Revista chilena de cirugía, 2009
Internal hernia of Meckel diverticulum in elderly patient Meckel Diverticulum is the most frequent gastrointestinal congenital anomaly. General population incidence is 2%. Complications develop in 4 to 30% of the cases, where over 50% present during the first decade.
MARIO ESTRELLA R, JOSÉ BERNAL R, LORETO FUENZALIDA C   +2 more
openaire   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

¿POR QUÉ ENSEÑAR GERIATRÍA DESDE EL PREGRADO?

Medicentro, 2011
El envejecimiento poblacional de la sociedad cubana es una realidad de gran interés por su tendencia al crecimiento. Cuba será, en los próximos cincuenta años, el país del Tercer Mundo más envejecido; alcanzó un 17,0 % de senescentes en el 20091.
Dr. Ángel Isern Menéndez, Dr. Gilberto García Puentes   +1 more
doaj  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Influencia del factor de crecimiento fibroblástico 2 en células madre in vitro

Actualidades Biológicas, 2020
El interés y la necesidad de estudiar las células madre en terapias regenerativas han aumentado en los últimos años debido a su capacidad de proliferación y diferenciación hacia múltiples linajes.
Andrea Catalina Rubio Vargas, Jessica Paola Alcázar Arzuza, Liliana Francis Turner   +2 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Desenvolvimento de angelônia em vaso, sob doses de adubo de liberação lenta

Ornamental Horticulture, 2018
Angelonia integerrima é uma espécie nativa que possui potencial ornamental podendo ser cultivada em canteiros, floreiras, vasos, ou ainda ser utilizada como complemento em arranjos florais.
Mara Cíntia Winhelmann, Aquélis Armiliato Emer, Marília Tedesco, Priscila Paris, Claudimar Sidnei Fior, Gilmar Schafer   +5 more
doaj   +1 more source