Results 61 to 70 of about 32,696 (317)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Influence of voice and hearing changes in the quality of life of active elderly individuals [PDF]

, 2014
This article seeks to verify the self-rated impact of voice and hearing changes of active elderly individuals in their daily lives, and the influence of this self-rating on quality of life.
Chiari, Brasilia Maria, Chiossi, Julia Santos Costa, Goulart, Bárbara Niegia Garcia de, Roque, Francelise Pivetta   +3 more
core   +4 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Tipos funcionais de plantas em resposta a variável ambiental relevo em pastagem natural na depressão central do RS. [PDF]

, 2019
O estudo foi realizado na Estação Experimental Agronômica da Faculdade de Agronomia da Universidade Federal do Rio Grande do Sul em uma área de aproximadamente três hectares, durante o período de dezembro/2002 a fevereiro de 2003, com o objetivo de ...
MEDEIROS, R. B. de, MORAES, S. A. de, ROSA, C. B. da, SANTOS, B. R. C. dos, SILVA, M. A. da, SOSINSKI, E., VOLTOLINI, T. V.   +6 more
core  

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Nature, 2016
Cellular senescence, a stress-induced irreversible growth arrest often characterized by expression of p16Ink4a (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a distinctive secretory phenotype, prevents the proliferation of preneoplastic cells
D. Baker, Bennett G. Childs, Matej Durik, M. Wijers, Cynthia J. Sieben, Jian Zhong, Rachel Saltness, K. Jeganathan, Grace C. Versoza, A. Pezeshki, K. Khazaie, Jordan D. Miller, J. V. van Deursen   +12 more
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Contenido clorofílico del epifiton sobre scirpus californicus en la laguna La Rosita (partido de Castelli) [PDF]

, 2008
Fil: Dos Santos, Analía. Departamento Científico Ficología. Museo de La Plata. Facultad de Ciencias Naturales y Museo, UNLPFil: Cano, María Gabriela. Departamento Científico Ficología. Museo de La Plata.
Cano, María Gabriela, Casco, María Adela, Dos Santos, Analía   +2 more
core  

Labio senescente. Clasificación clínica y tratamiento quirúrgico

, 2020
Resumen Introducción y objetivo. El labio senescente se produce por cambios relacionados con el paso del tiempo a nivel de piel, tejido celular subcutáneo, músculo y hueso, con el resultado de elongación y pérdida de volumen del labio. Proponemos una clasificación clínica del labio senescente a fin de establecer el tratamiento quirúrgico del mismo ...
Sánchez Silva,Bianca, Quintero Larróvere,Milagro   +1 more
openaire   +1 more source

SGLT2 inhibition eliminates senescent cells and alleviates pathological aging

Nature Aging
It has been reported that accumulation of senescent cells in various tissues contributes to pathological aging and that elimination of senescent cells (senolysis) improves age-associated pathologies. Here, we demonstrate that inhibition of sodium–glucose
G. Katsuumi, I. Shimizu, M. Suda, Y. Yoshida, T. Furihata, Y. Joki, C. Hsiao, Liang Jiaqi, S. Fujiki, Manabu Abe, Masataka Sugimoto, Tomoyoshi Soga, Tohru Minamino   +12 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source