Results 71 to 80 of about 32,696 (317)

Senescent glia link mitochondrial dysfunction and lipid accumulation

Nature
Senescence is a cellular state linked to ageing and age-onset disease across many mammalian species1,2. Acutely, senescent cells promote wound healing3,4 and prevent tumour formation5; but they are also pro-inflammatory, thus chronically exacerbate ...
China N. Byrns, Alexandra E. Perlegos, Karl N. Miller, Zhecheng Jin, F. Carranza, Palak Manchandra, Connor H. Beveridge, Caitlin E. Randolph, V. S. Chaluvadi, Shirley L. Zhang, Ananth R. Srinivasan, F. C. Bennett, A. Sehgal, P. Adams, Gaurav Chopra, Nancy M. Bonini   +15 more
semanticscholar   +1 more source

A proteomic atlas of senescence-associated secretomes for aging biomarker development

bioRxiv, 2019
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of, and promising therapeutic target for, multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically assessed by a
Nathan Basisty, Abhijit Kale, Ok-hee Jeon, Chisaka Kuehnemann, Therese Payne, Chirag Rao, A. Holtz, Samah Shah, Vagisha Sharma, L. Ferrucci, J. Campisi, B. Schilling   +11 more
semanticscholar   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Desenvolvimento de angelônia em vaso, sob doses de adubo de liberação lenta

Ornamental Horticulture, 2018
Angelonia integerrima é uma espécie nativa que possui potencial ornamental podendo ser cultivada em canteiros, floreiras, vasos, ou ainda ser utilizada como complemento em arranjos florais.
Mara Cíntia Winhelmann, Aquélis Armiliato Emer, Marília Tedesco, Priscila Paris, Claudimar Sidnei Fior, Gilmar Schafer   +5 more
doaj   +1 more source

Influencia del factor de crecimiento fibroblástico 2 en células madre in vitro

Actualidades Biológicas, 2020
El interés y la necesidad de estudiar las células madre en terapias regenerativas han aumentado en los últimos años debido a su capacidad de proliferación y diferenciación hacia múltiples linajes.
Andrea Catalina Rubio Vargas, Jessica Paola Alcázar Arzuza, Liliana Francis Turner   +2 more
doaj   +1 more source

Efeito de concentrações de um fertilizante solúvel no cultivo in vitro da variedade de mandioca (Manihot Esculenta Crantz) batata (BGM 1660). [PDF]

, 2014
A Mandioca (Manihot esculenta Crantz) é considerada um alimento de subsistência para mais de 500 milhões de pessoas em áreas tropicais, apresentando uma produção mundial em 2012 de aproximadamente 256 milhões toneladas de raízes.
MENEZES, M. C., SANTOS, E. B., SILVEIRA, D. M. de S., SOUZA, A. da S., SOUZA, K. A. de, VIDAL, Á. M.   +5 more
core  

Cellular senescence: Neither irreversible nor reversible

Journal of Experimental Medicine
Cellular senescence is a stress-inducible terminal cell-cycle arrest program with far-reaching pathophysiologic implications. This Review summarizes the evidence that senescent cells need to actively maintain their arrest machinery and discusses the ...
M. Reimann, Soyoung Lee, Clemens A. Schmitt   +2 more
semanticscholar   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Emerging role of senescent microglia in brain aging-related neurodegenerative diseases

Translational Neurodegeneration
Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), but the intricate interplay between brain aging and the pathogenesis of ...
Changil Rim, M. You, Minyeop Nahm, M. Kwon   +3 more
semanticscholar   +1 more source

Senolytic CAR T cells reverse senescence-associated pathologies

Nature, 2020
Cellular senescence is characterized by stable cell-cycle arrest and a secretory program that modulates the tissue microenvironment1,2. Physiologically, senescence serves as a tumour-suppressive mechanism that prevents the expansion of premalignant ...
Corina Amor, J. Feucht, J. Leibold, Yu-jui Ho, Changyu Zhu, Direna Alonso-Curbelo, J. Mansilla-Soto, Jacob A Boyer, Xiang Li, Theodoros Giavridis, Amanda Kulick, Shauna L. Houlihan, E. Peerschke, S. Friedman, V. Ponomarev, A. Piersigilli, M. Sadelain, S. Lowe   +17 more
semanticscholar   +1 more source