Results 91 to 100 of about 690,894 (266)
Advanced Science, EarlyView.Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang +8 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang +8 more
wiley +1 more source
Multiscale Circuit Architecture Associated With Memory Dysfunction in Temporal Lobe Epilepsy
Advanced Science, EarlyView.A multiscale precision‐mapping framework reveals that memory impairment in temporal lobe epilepsy arises from the convergence of focal medial temporal pathology, strategic white matter disconnection, and limbic‐centered metabolic network dysfunction.
Jiajie Mo +12 more
wiley +1 more source
Preferences outgoing students of the University of the Third Age in Wabrzezno
Journal of Education, Health and Sport, 2016 The article concerns to specify preferences and trends and themes tourist trips. The study included 52 students of the University of the Third Age (UTA) in Wąbrzeźno (Poland). The results showed that 35% of respondents spend free time at home. Those who
Eliza Maria Zielińska +2 more
doaj
A non-randomized pilot study to test the feasibility of developing a frailty scale for pet cats
Frontiers in Veterinary ScienceIntroductionHuman frailty has long been studied and dozens of “frailty scales” have been developed, but equivalent research is more limited in cats. This pilot study aimed to determine the feasibility of recruiting and retaining veterinary practices and ...
Elizabeth J. Colleran +14 more
doaj +1 more source
A Multimodal Haptic Feedback Interface with Thin‐Film Compliant Mechanism
Advanced Science, EarlyView.Multimodal haptic devices can trigger different mechanoreceptors, enabling richer haptic information. This study presents an electromagnetic multimodal haptic device capable of delivering indentation, stretch, and vibration stimuli. The device is enabled by a novel polymer thin‐film compliant mechanism that provides high translational compliance along ...
Jingjing Wan +15 more
wiley +1 more source
Advanced Science, EarlyView.This study develops a multi‐dimensional vision Transformer‐based model, GAVR, to accurately distinguish gastric cancer T4a/b stages preoperatively. Validated across multi‐center cohorts, it achieves excellent performance and significantly improves radiologists’ diagnostic accuracy, offering a promising tool for clinical decision‐making.
Guoliang Zheng +20 more
wiley +1 more source
Ciencia y Enfermería, 2004 A família é o esteio do idoso, seja afetivo, como suporte para o cuidado, e financeiro, quando sua renda é insuficiente para seu auto-sustento. Mas a família está reduzida em seu tamanho e seus valores sofrem fortes transformações.
MARIA JOSEFINA DA SILVA +2 more
doaj
Senior Chemistry Senior Magnetism and Electricity Senior Heat [PDF]
Nature, 1911 openaire +1 more source