Results 81 to 90 of about 722,067 (266)

An Interpretable, Data‐Driven, Hierarchical Multi‐Domain Fusion Framework for Classification and Motor Function Scoring in Chronic Ankle Instability

Advanced Science, EarlyView.
An AI‐enabled digital twin framework integrates wearable EMG sensing with hierarchical multi‐domain fusion to classify chronic ankle instability, distinguish clinically relevant subtypes, and generate continuous motor function scores. Clinically interpretable functional stratification and SHAP‐based biomarker analysis provide transparent decision ...
Tianle Jie, Datao Xu, Zhifeng Zhou, Bas Van Hooren, Huiyu Zhou, Yi Yuan, Xiangli Gao, Monèm Jemni, Liangliang Xiang, Meizi Wang, Justin Fernandez, Tibor J. Goda, Yaodong Gu   +12 more
wiley   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

Advanced Science, EarlyView.
Tumor‐associated inflammation retains antibody‐targeted or non‐specific antibody conjugated nanoparticles within the tumor microenvironment. Magnetic Particle Imaging (MPI) enables non‐invasive detection and differentiation of tumors from other organs, owing to higher nanoparticle retention by inflammatory cells in the tumor periphery.
Preethi Korangath, Hayden Carlton, Theresa Wong, Sean Healy, Toby Sanders, Mason Song, Patrick W. Goodwill, Cordula Grüttner, Kathleen Gabrielson, Robert Ivkov   +9 more
wiley   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Reversible, Chemically Gated FRET via Ligand‐Activated Acceptors

Advanced Science, EarlyView.
Fluorogen binding turns the compact FAST tag into a tunable FRET acceptor, with ligand chemistry programming spectral overlap and excited‐state lifetimes. Fluorescence‐lifetime imaging reads out energy transfer through the shortened donor lifetime, while simply adding or washing out the dye switches FRET on and off, reversibly mapping the supramodular ...
Nivedita Singh, Smruti Ranjan Nayak, Sanjay Kumar Mohanty, Aishwarya Hanumantharaju, Amala Shaju, Mini Jose, Aravind Penmatsa, Deepak Nair   +7 more
wiley   +1 more source

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

Advanced Science, EarlyView.
The schematic diagram depicts a compartmentalized anti‐ferroptotic defense mechanism mediated by GSTA4. GSTA4 is upregulated and localizes to the cytoplasm in ENZR cells, where it detoxifies 4‐HNE via a non‐canonical GSH‐dependent pathway. Under oxidative stress, GSTA4 translocates to mitochondria, interacts with PGAM5, and blocks Drp1 Ser637 ...
Yong Luo, Wei Zhuang, Zean Li, Yiming Lai, Yongyi Ou, Dongquan Li, Shanhe Huang, Tianlong Luo, Jintao Hu, Bingliang Chen, Jianhan Fu, Tao Zhuo, Hankun Jiang, Yin Lu, Hai Huang, Kewei Xu, Shengmeng Peng, Qing Yuan   +17 more
wiley   +1 more source

An Expertise Transfer Framework For Autonomous Surgical Assistance

Advanced Science, EarlyView.
This study introduces an expertise transfer framework for procedure‐spanning autonomous surgical assistance. By emulating expert logic through hierarchical perception, attention modeling, and knowledge graph‐based decision‐making, the system provides near‐expert surgical view assistance.
Yuan Gao, Guangdi Chu, Wei Jiao, Yuchuan Zhong, Hang Yuan, Chengjun Li, Jinhua Li, Shuxin Wang, Bo Guan, Jianchang Zhao, Lizhi Pan, Haitao Niu, Jianmin Li   +12 more
wiley   +1 more source

Preferences outgoing students of the University of the Third Age in Wabrzezno

Journal of Education, Health and Sport, 2016
The article concerns to specify preferences and trends and themes tourist trips. The study included 52 students of the University of the Third Age (UTA) in Wąbrzeźno (Poland). The results showed that 35% of respondents spend free time at home. Those who
Eliza Maria Zielińska, Gabriela Barwińska-Szczutkowska, Sylwia Barwińska   +2 more
doaj  

Distribution and determinants of the utilization of senior residential care homes in Saudi Arabia: a cross-sectional study

Frontiers in Public Health
BackgroundWith the accelerated increase in the population of seniors aged 60 years or older in Saudi Arabia, understanding the utilization of senior residential care homes is crucial for improving service delivery and policy planning to meet the care ...
Saad M. Bindawas, Vishal Vennu, Maha Almarwani, Walid Alkeridy, Walid Alkeridy, Walid Alkeridy   +5 more
doaj   +1 more source