Results 151 to 160 of about 321,342 (308)

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Du potentiel sémantique au signifié dialogique

Arts et Savoirs, 2012
Francesco La Mantia
doaj   +1 more source

Detection and Potency Classification of Pre- and Pro-Haptens Using the SENS-IS Assay: The Role of Metabolically Competent Reconstructed Skin. [PDF]

Toxics
Cottrez F, Boitel E, Sahli E, Bastard M, Capallere C, Groux H.   +5 more
europepmc   +1 more source

Donner du sens aux apprentissages en EPS

, 2000
Cette conférence visait à envisager la question du sens en EPS et ses implications pour une pédagogie du sens dans cette discipline en appui sur une analyse des travaux relatifs au sens conduits dans le champ des sciences de l ...
Fargier, Patrick
core  

Architecture‐Engineered Semi‐Crystalline Microporous Polymer Membranes for Precise Molecular Separation

Advanced Science, EarlyView.
Guided by a Random Forest model, a π–π‐driven ordered stacking strategy deploys functionally distinct substructures to restrict chain segment motion and increase free volume, while preserving the intermolecular interactions that maintain structural integrity.
Zi‐Meng Xu, Hao Zhuo, Song‐Hui Zhi, Xiao‐Feng Zhong, Pan‐Pan Zhang, Si‐Yuan Yang, Wen‐Yong Yang, Guang‐Yong Shen, Ya‐Zhao Li, Yi Li, Ming Xue   +10 more
wiley   +1 more source

Recurring Temporal Association Between Influenza A Epidemics and Subsequent Influenza B Dominance in Post-Pandemic Korea, 2022-2026. [PDF]

J Med Virol
Lee Y, Yoon Y, Park JE, Kim WK, Choi YY, Kim YK, Kang C, Yoo Y, Choe YJ.   +8 more
europepmc   +1 more source

La mouche sous un verre / Jeanne-Marie Sens

, 1994
Collection : [Écris-moi]Contient une table des matièresAvec mode ...
Sens, Jeanne-Marie (1937-....). Auteur du texte
core  

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

Monitub: A Low-Cost Real-Time System for Long-Term Methane Emissions Monitoring from Inland Waterbodies. [PDF]

Sensors (Basel)
Duncan B, Grinham A, D'Souza M, Deering N.   +3 more
europepmc   +1 more source

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source