Results 231 to 240 of about 8,451,938 (279)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The mediating role of public belonging in the relationship between competitive sports participation, loneliness, and self-harm among adolescents. [PDF]

Front Psychiatry
Liang Y, Chen C, Liu S.
europepmc   +1 more source

Memoria [PDF]

Métges sense Fronteres (Associació)
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

The mediating role of positive mental attitude in the relationship between mental toughness and athlete burnout: a cross-sectional study. [PDF]

Front Public Health
Bojkowski Ł.
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

How museum-based creative-product experiences shape cultural confidence via cultural cognition and cultural identity. [PDF]

Front Psychol
Xia J, Li Y, He Y, Ma K.
europepmc   +1 more source

Rethinking personhood and agency: how AI challenges human-centered concepts. [PDF]

Front Psychol
Gao L, Mvondo GFN.
europepmc   +1 more source

The Sense of Belonging Quotient: Relating Sense of Belonging to Predictors of Scientific Civic Engagement and Science Identity in Civically Engaged Curricula. [PDF]

CBE Life Sci Educ
Alam I, Bilinski T, Bernot KM, Cotter R, Ortiz-Zuazaga E, Vance-Chalcraft HD, Corwin LA.   +6 more
europepmc   +1 more source

What role do self-regulatory mechanisms play in the risky use of digital media by adolescents? [PDF]

Front Psychol
Hrbackova K, Hladík J, Petr Safrankova A.   +2 more
europepmc   +1 more source