Results 171 to 180 of about 822,405 (289)

A glucose-sensing mechanism with glucose transporter 1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats. [PDF]

J Biol Chem, 2023
Li RJW, Chiu JFM, Bruce K, Zhang SY, Barros DR, Yue JTY, Lam TKT.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Nir2 crystal structures reveal a phosphatidic acid-sensing mechanism at ER-PM contact sites. [PDF]

Proc Natl Acad Sci U S A
Kim D, Lee S, Jun Y, Lee C.
europepmc   +1 more source

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism. [PDF]

Antioxidants (Basel), 2021
Olson KR.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Triarylpyrylium-based fluorescent DNA-binding dyes - facile synthesis, substituent effects, and sensing mechanism. [PDF]

RSC Adv
Domahidy F, Cseri L, Turczel G, Huszár B, Rózsa BJ, Mucsi Z, Kovács E.   +6 more
europepmc   +1 more source

Surface Plasmonic Sensors: Sensing Mechanism and Recent Applications. [PDF]

Sensors (Basel), 2021
Duan Q, Liu Y, Chang S, Chen H, Chen JH.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A Comparative Study on the Wake Sensing Mechanism of a Seal Whisker-Shaped Cylinder. [PDF]

Sensors (Basel)
Mao Y, Chang H, Wang Y, Yuan D, Lv Y, Song Z.   +5 more
europepmc   +1 more source

Novel oxygen sensing mechanism in the spinal cord involved in cardiorespiratory responses to hypoxia. [PDF]

Sci Adv, 2022
Barioni NO, Derakhshan F, Tenorio Lopes L, Onimaru H, Roy A, McDonald F, Scheibli E, Baghdadwala MI, Heidari N, Bharadia M, Ikeda K, Yazawa I, Okada Y, Harris MB, Dutschmann M, Wilson RJA.   +15 more
europepmc   +1 more source