Results 61 to 70 of about 1,009,466 (301)

Obscured clusters.I. GLIMPSE30 - Young Milky Way Star Cluster Hosting Wolf-Rayet Stars

, 2007
Young massive clusters are perfect astrophysical laboratories for study of massive stars. Clusters with Wolf-Rayet (WR) stars are of special importance, since this enables us to study a coeval WR population at a uniform metallicity and known age ...
Benjamin, Borissova, Borissova, Borissova, Conti, Cotera, Crowther, Crowther, Crowther, Figer, Figer, Figer, Forestini, Hamann, Hanson, Hillier, Ivanov, Ivanov, J. Borissova, Koornneef, L. Georgiev, Lamers, Maiolino, Mercer, Meynet, Moorwood, R. Kurtev, Rieke, S. Ortolani, Skrutskie, Stetson, Taylor, V. D. Ivanov, van der Hucht, van der Hucht   +34 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AdSplit: Separating smartphone advertising from applications [PDF]

, 2012
A wide variety of smartphone applications today rely on third-party advertising services, which provide libraries that are linked into the hosting application. This situation is undesirable for both the application author and the advertiser.
Dietz, Michael, Shekhar, Shashi, Wallach, Dan S.   +2 more
core   +1 more source

Design and construction of a point-contact spectroscopy rig with lateral scanning capability

, 2016
The design and realization of a cryogenic rig for point-contact spectroscopy measurements in the needle-anvil configuration is presented. Thanks to the use of two piezoelectric nano-positioners, the tip can move along the vertical ($z$) and horizontal ...
Ascencio, C. O., Greene, L. H., Park, W. K., Saraf, P., Tortello, M.   +4 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

ImageJS: Personalized, participated, pervasive, and reproducible image bioinformatics in the web browser

Journal of Pathology Informatics, 2012
Background: Image bioinformatics infrastructure typically relies on a combination of server-side high-performance computing and client desktop applications tailored for graphic rendering.
Jonas S Almeida, Egiebade E Iriabho, Vijaya L Gorrepati, Sean R Wilkinson, Alexander Grüneberg, David E Robbins, James R Hackney   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Illuminating Hidden Pulsars: Scintillation-enhanced Discovery of Two Binary Millisecond Pulsars in M13 with FAST

The Astrophysical Journal
We conducted a sensitive acceleration search using fast Fourier transform techniques on full-length and segmented data from 84 observations of the globular cluster M13 with the Five-hundred-meter Aperture Spherical radio Telescope.
Dejiang Yin, Lin Wang, Li-yun Zhang, Lei Qian, Baoda Li, Kuo Liu, Bo Peng, Yinfeng Dai, Yaowei Li, Zhichen Pan   +9 more
doaj   +1 more source

MedicalFuzzySec: A novel steganography technique using fuzzy logic to secure electronic patient data (EPD) concealment in medical images

Cyber Security and Applications
Medical diagnostic systems generate sensitive patient information that requires optimal protection during transmission and storage. Image steganography provides a secure method for embedding secret data, making it imperceptible to the naked eye as part ...
Moh Rosy Haqqy Aminy, Ntivuguruzwa Jean De La Croix, Tohari Ahmad, Emmanuel Bugingo, François Xavier Rugema   +4 more
doaj   +1 more source