Results 81 to 90 of about 4,715,263 (253)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Sensitive review report

open access: yes, 2008
Title from PDF caption (viewed on December 10, 2019).Covers OCLC #1130237092, OCLC #1130236611, and OCLC #1130236422.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

Inverse kinematic analysis for triple-octahedron variable-geometry truss manipulators [PDF]

open access: yes, 2001
In this paper, a new triple-octahedron variable-geometry truss manipulator is presented. Its inverse kinematic solutions in closed form are studied. An input-output displacement equation in one output variable is derived.
Xu, L. J.   +7 more
core   +1 more source

VS-GRU: A Variable Sensitive Gated Recurrent Neural Network for Multivariate Time Series with Massive Missing Values

open access: yesApplied Sciences, 2019
Multivariate time series are often accompanied with missing values, especially in clinical time series, which usually contain more than 80% of missing data, and the missing rates between different variables vary widely. However, few studies address these
Qianting Li, Yong Xu
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Paired catchment research reveals WSUD influences on stream ecosystem condition at average and low residential densities

open access: yes, 2013
Catchment characteristics that if present concurrently support improvement in stream ecosystem health following urban development include riparian vegetation, stormwater treatment via raingardens, ponds elevated above the riparian corridor and forest ...
van Roon, MR
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Modulo-Variable Expansion Sensitive Scheduling

open access: yes, 1998
Modulo scheduling is an aggressive scheduling technique for loops that exploit instruction-level parallelism by overlapping successive iterations of the loop.
Govindarajan, R, Valluri, Madhavi Gopal
core  

Impact of photon noise on the reliability of a motion-sensitive neuron in the fly's visual system [PDF]

open access: yes, 2003
Grewe J, Kretzberg J, Warzecha A-K, Egelhaaf M. Impact of photon noise on the reliability of a motion-sensitive neuron in the fly's visual system. The journal of neuroscience.
Grewe, Jan   +3 more
core  

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