Results 61 to 70 of about 98,745 (247)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Design and Parametric Sensitivity Analysis of a Steel-Concrete Hybrid Semi-Submersible Foundation Supporting a 15 MW Wind Turbine

open access: yesJournal of Marine Science and Engineering
With the rapidly growing global demand for clean energy, offshore wind power has become an important renewable energy source. To clarify how the principal dimensions affect the performance of a 15 MW-class floating wind turbine platform in 100 m water ...
Wenwen Hu   +6 more
doaj   +1 more source

UNCERTAIN MODEL OF REACTOR IN PROCESS OF PRODUCTION GREASE ON SOAP THICKENERS

open access: yesВісник Національного технічного університету України «Київський політехнічний інститут імені Ігоря Сікорського»: Серія «Хімічна інженерія, екологія та ресурсозбереження», 2017
In this article consider the problem of guaranteed quality controlled processes with uncertain parameters of the functional components of management, set interval or fuzzy way.
Антон Петрович Коротинський   +1 more
doaj   +1 more source

Differential Stability of Convex Discrete Optimal Control Problems

open access: yes, 2017
Differential stability of convex discrete optimal control problems in Banach spaces is studied in this paper. By using some recent results of An and Yen [Appl. Anal.
An, Duong Thi Viet, Toan, Nguyen Thi
core   +1 more source

On the local stability of semidefinite relaxations

open access: yes, 2020
We consider a parametric family of quadratically constrained quadratic programs (QCQP) and their associated semidefinite programming (SDP) relaxations. Given a nominal value of the parameter at which the SDP relaxation is exact, we study conditions (and ...
Agarwal, Sameer   +3 more
core   +1 more source

Sequential sampling strategy for the modeling of parameterized microwave and RF components [PDF]

open access: yes, 2011
Accurate modeling of parameterized microwave and RF components often requires a large number of full-wave electromagnetic simulations. In order to reduce the overall simulation cost, a sequential sampling algorithm is proposed that selects a sparse set ...
Crombecq, Karel   +3 more
core   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Behavior of steel columns with double curvature: a numerical simulation and design-oriented parametric study

open access: yesFracture and Structural Integrity
This research present a novel investigation, which focuses on the numerical exploration of steel columns having a double curvature, built with both hollow square and circular cross-sections.
Hamda Guedaoura   +4 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Power Transformer Vibration Analysis Model Based on Ensemble Learning Algorithm

open access: yesIEEE Access
The inflow of DC magnetic flux into the core of power transformers under DC bias conditions leads to a significant increase in operational losses, noise levels, and vibration amplitudes, posing substantial threats to the stability and reliability of the ...
Baidi Shi   +6 more
doaj   +1 more source

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