Results 51 to 60 of about 98,745 (247)
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Applied SciencesThe dynamic response of pump valve motion directly influences the volumetric efficiency of drilling pumps and serves as a critical factor in performance enhancement.
Yi Wu, Yongjun Hou
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Numerical-simulation hybrid analysis of orthogonal cutting of Inconel 718
Journal of Mechanical Engineering and SciencesInconel 718 is widely employed in the aerospace and energy sectors due to its exceptional mechanical and thermal stability, yet it remains one of the most challenging materials to machine.
Md Adan Maqsood +4 more
doaj +1 more source
Local strong maximal monotonicity and full stability for parametric variational systems [PDF]
, 2014 The paper introduces and characterizes new notions of Lipschitzian and H\"olderian full stability of solutions to general parametric variational systems described via partial subdifferential and normal cone mappings acting in Hilbert spaces.
Mordukhovich, B. S., Nghia, T. T. A.
core
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
EngMachining Nomex honeycomb structures presents a major challenge due to their thin-walled architecture, orthotropic behavior, and sensitivity to adhesion and delamination.
Oussama Beldi +7 more
doaj +1 more source
, 2013 Model reduction methods often aim at an identification of slow invariant manifolds in the state space of dynamical systems modeled by ordinary differential equations.
Lebiedz, Dirk, Siehr, Jochen
core +1 more source
Sensitivity analysis using data-driven parametric macromodels [PDF]
, 2011 An accurate parametric macromodeling method which builds the parameterized frequency behavior of systems from frequency data samples is presented.
Chemmangat Manakkal Cheriya, Krishnan +3 more
core +2 more sources