Results 111 to 120 of about 8,396,703 (346)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Analyzing Cost Overrun Risks in Construction Projects: A Multi-Stakeholder Perspective Using Fuzzy Group Decision-Making and K-Means Clustering

Buildings
The current research investigates cost overrun factors in structural projects, focusing on the Middle East and North Africa (MENA) region using Egypt as a model.
Ahmed Mohammed Abdelalim, Maram Salem, Mohamed Salem, Manal Al-Adwani, Mohamed Tantawy   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Design and Performance Evaluation of SiPM-based High-resolution Dedicated Brain Positron Emission Tomography Scanner: A Simulation Study

Journal of Medical Physics
Purpose/Aim: The increasing population age highlights the critical need for early brain disease diagnosis, especially in disorders such as dementia. Consequently, a notable focus has been on developing dedicated brain positron emission tomography (PET ...
Tahereh Zare, Peyman Sheikhzadeh, Behnoosh Teimourian Fard, Pardis Ghafarian, Mohammad Reza Ay   +4 more
doaj   +1 more source

Antibiotic sensitivity of the causative microorganisms of subclinical mastitis in lactating sheep

Животновъдни науки, 2022
The aim of the presented research is to determine the antibiotic sensitivity and resistance of the microorganisms causing subclinical mastitis in dairy sheep.
Aleksandar Stoimenov, Teodora Popova, Georgi Stoimenov, Kalin Hristov   +3 more
doaj  

Dataset relative to article "Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy"

, 2021
Giuseppe Liberatore, Claudia Giannotta, Blesson Punnen Sajeev, Emanuela Morenghi, Fabrizia Terenghi, Francesca Gallia, Pietro Emiliano Doneddu, Fiore Manganelli, Dario Cocito, Massimiliano Filosto, Giovanni Antonini, Giuseppe Cosentino, Girolama Alessandra Marfia, Angelo Maurizio Clerici, Giuseppe Lauria, Tiziana Rosso, Guido Cavaletti, Eduardo Nobile‐Orazio   +17 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A Simulation Study for Optimal Pinhole Collimator Design in Gamma Camera Systems

Journal of Medical Physics
Background: The usage of a semiconductor detector with a pinhole collimator can provide high spatial resolution due to its high intrinsic resolution. However, the collimator system has low sensitivity due to the hole’s small diameter.
M. A. Ghoneim
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source