Results 91 to 100 of about 5,431,305 (239)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Analyzing Cost Overrun Risks in Construction Projects: A Multi-Stakeholder Perspective Using Fuzzy Group Decision-Making and K-Means Clustering

Buildings
The current research investigates cost overrun factors in structural projects, focusing on the Middle East and North Africa (MENA) region using Egypt as a model.
Ahmed Mohammed Abdelalim, Maram Salem, Mohamed Salem, Manal Al-Adwani, Mohamed Tantawy   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Fasciola hepatica: can the coproantigen ELISA replace the faecal egg sedimentation test?

Veterinary Evidence
Question In adult cattle, is the sensitivity of the coproantigen ELISA test equal or superior to the sensitivity of the faecal egg sedimentation test for the diagnosis of Fasciola hepatica?   Clinical bottom line The category of research question
Jake Collyer
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Design and Performance Evaluation of SiPM-based High-resolution Dedicated Brain Positron Emission Tomography Scanner: A Simulation Study

Journal of Medical Physics
Purpose/Aim: The increasing population age highlights the critical need for early brain disease diagnosis, especially in disorders such as dementia. Consequently, a notable focus has been on developing dedicated brain positron emission tomography (PET ...
Tahereh Zare, Peyman Sheikhzadeh, Behnoosh Teimourian Fard, Pardis Ghafarian, Mohammad Reza Ay   +4 more
doaj   +1 more source

Antibiotic sensitivity of the causative microorganisms of subclinical mastitis in lactating sheep

Животновъдни науки, 2022
The aim of the presented research is to determine the antibiotic sensitivity and resistance of the microorganisms causing subclinical mastitis in dairy sheep.
Aleksandar Stoimenov, Teodora Popova, Georgi Stoimenov, Kalin Hristov   +3 more
doaj  

Sensitivity of Pareto Solutions in Multiobjective Optimization. [PDF]

The paper presents a sensitivity analysis of Pareto solutions on the basis of the Karush-Kuhn-Tucker (KKT) necessary conditions applied to nonlinear multiobjective programs (MOP) continuously depending on a parameter.
Balbás, Alejandro, Jiménez Guerra, Pedro, Galperin, Effim   +2 more
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Localisation and conflict sensitivity::Lessons on good practice from South Sudan

, 2021
There is still much to be understood about South Sudan’s dynamic context. However, there is a wealth ofexisting research, knowledge, experience, and ongoing discussions around localisation in South Sudan.
Robinson, Alice; id_orcid
core   +1 more source