Results 81 to 90 of about 4,655,855 (296)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2005 Interleukin 6 (IL-6) may represent an early marker of inflammatory activation and may be useful to ameliorate risk stratification in patients with ischemic heart disease.
BATTAGLIA D +5 more
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Appendix C Sensitivity of Stochastic Models Hansen, T. M. and Singh, S, April 1997
, 2007 Contents C Sensitivity Analysis of Stochastic Models of the Crust 1 C.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 C.2 Fractal Nature of the Crust . . . . . . . . . . . . . . . . . . . . . . . . . . .
Sensitivity Of Stochastic
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
, 2023 There is a growing body of research that examines anxiety sensitivity (i.e., fear of arousal-based sensations) and physical activity. This research has tended to show that individuals with higher levels of anxiety sensitivity engage in lower levels of ...
DeWolfe, Christopher
core
Sensitivity-analysis for dry rate n (%) for patients treated with AUS.
, 2023 Sensitivity-analysis for dry rate n (%) for patients treated with AUS.
Qin Yang (25816) +2 more
core +1 more source
Optimization of Nanowell-Based Label-Free Impedance Biosensor Based on Different Nanowell Structures
BiosensorsNanowell-based impedance-based label-free biosensors have demonstrated significant advantages in sensitivity, simplicity, and accuracy for detecting cancer biomarkers and macromolecules compared to conventional impedance-based biosensors.
Ali Fardoost +2 more
doaj +1 more source
Annals of Nutrition and Metabolism, 2015 Non-celiac gluten sensitivity (NCGS) is a syndrome characterized by intestinal and extraintestinal symptoms related to the ingestion of gluten-containing food in subjects who are not affected by either celiac disease (CD) or wheat allergy (WA). The prevalence of NCGS is not clearly defined yet.
openaire +2 more sources