Results 71 to 80 of about 8,396,703 (346)

Burst Populations and Detector Sensitivity

, 2003
The F_T (peak bolometric photon flux) vs. E_p (peak energy) plane is a powerful tool to compare the burst populations detected by different detectors. Detector sensitivity curves in this plane demonstrate which burst populations the detectors will detect.
Band, David L.
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Evaluating alternatives to the Widal test for typhoid fever diagnosis in developing countries: A targeted literature review

Journal of Public Health in Africa
Background: Typhoid disease, caused by Salmonella typhi, is prevalent in developing countries with poor sanitation. The Widal test, despite its century-old history, has drawbacks in diagnostic capacity because of inherent characteristics, cross ...
Bereket A. Tegene, Meron T. Eshetie
doaj   +1 more source

Antibiotic Sensitivity of Staph. aureus [PDF]

, 2017
Undergraduate Experimental ...
Hubbard, Dr. Randall, Martin, Stephen
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Establishment of an In-House Indirect Enzyme-Linked Immunosorbent Assay to Detect Antibodies Against African Horse Sickness Based on Monovalent and Polyvalent Live Attenuated Vaccines During the First Outbreak in Thailand

Animals
Standard serological tests post-vaccination, such as enzyme-linked immunosorbent assay (ELISA), complement fixation, and virus neutralization, are crucial for monitoring African horse sickness (AHS). However, the availability of commercial test kits such
Darsaniya Punyadarsaniya, Machimaporn Taesuji, Khate Rattanamas, Sakchai Ruenphet   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Derivative based global sensitivity measures

, 2015
The method of derivative based global sensitivity measures (DGSM) has recently become popular among practitioners. It has a strong link with the Morris screening method and Sobol' sensitivity indices and has several advantages over them.
A. Griewank, A. Kiparissides, A. Saltelli, A. Saltelli, A. Saltelli, B. Sudret, E. Patelli, E. Patelli, F. Campolongo, F. Campolongo, G. Hardy, G. Pujol, I. Sobol, I. Sobol, I. Sobol, I. Sobol, I. Sobol, I. Sobol, J. Friedman, J. Fruth, J. Santiago, J.M. Fédou, K. Jansen, M. Jansen, M. Lamboni, M. Morris, M. Rodriguez-Fernandez, O. Roustant, R. Cropp, R. Liu, S. Kucherenko, S. Kucherenko, S. Touzany, S.G. Bobkov, T. Homma, T. Muehlenstaedt   +35 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source