Results 241 to 250 of about 2,654,059 (402)

Sensitivity and specificity

, 2015
Matt Morgan, Stefan Tigges, Francesco Sciacca   +2 more
openaire   +1 more source

Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium

FEBS Open Bio, EarlyView.
By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita, Toyonobu Usuki, Robert R. Kay, Tamao Saito   +3 more
wiley   +1 more source

ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificity.

Journal of Proteomics, 2015
Tao Xu, Tao Xu, S. K. Park, John D. Venable, J. Wohlschlegel, J. Diedrich, D. Cociorva, Bingwen Lu, L. Liao, J. Hewel, Xuemei Han, C. Wong, B. Fonslow, C. Delahunty, Yu Gao, H. Shah, J. Yates   +16 more
semanticscholar   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Class-agnostic annotation of small RNAs balances sensitivity and specificity in diverse organisms. [PDF]

Comput Struct Biotechnol J
Johnson NR, Gonzalez-Toro F, Gomez BB.
europepmc   +1 more source

Utilization of Modified Touchdown qPCR to Enhance Sensitivity and Specificity for Genes with Restricted Expression and Low Optimum Temperature Primers

Koyuki Atifa Rahmi, Husnul Khotimah, Mohammad Saifur Rohman   +2 more
openalex   +1 more source

High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer’s disease phenotypes in a large mixed-dementia cohort [PDF]

Muhammad Junaid Ali, Yike Chen, Cyril Pottier, Geoffrey K. Feld, Tammie L.S. Benzinger, Cyrus A. Raji, Beau M. Ances, Brian A. Gordon, Julie K. Wisch, John C. Morris, David M. Holtzman, Carlos Cruchaga   +11 more
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Sensitivity and Specificity of Natural Language Processing Systems for Identification of Hospitalized People Who Use Drugs. [PDF]

Open Forum Infect Dis
Benrubi L, Sato T, Westgard LK, Zollo-Venecek K, Socrates B, Sweigart B, Ridgway JP, Suzuki J, Morales Y, Goodman-Meza D, Wurcel AG.   +10 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source