Results 241 to 250 of about 2,163,703 (333)

Reliability of Frozen Section Biopsy in Detecting Endometrial Pathologies: A Systematic Review of Sensitivity and Specificity. [PDF]

Cureus
Ali Mohammed MA, TalbAllah SM, Edris Mohamed MA, Abdalla Hamrawi NW, Elamin Osman AM, Salih Elfaki TI.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Diagnostic sensitivity and specificity of metagenomic sequencing and qPCR for detection of viruses associated with bovine respiratory disease estimated using Bayesian latent class models. [PDF]

Front Vet Sci
Donbraye E, McLeod L, Chai Z, Lacoste SR, McCarthy EL, Hill JE, Erickson NEN, Links MG, Otto SJG, Huang Y, Waldner CL.   +10 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Sensitivity and Specificity of Serial Focused Assessment With Sonography in Trauma (FAST) in Patients With Blunt Abdominal Trauma. [PDF]

Cureus
Kakran A, Singh R, Chaudhary P, Chaudhary AK, Saquib Ali M.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Methodological choices strongly modulate the sensitivity and specificity of lesion-symptom mapping analyses

Moore MJ, Rorden C, Robinson GA, Mattingley JB, Demeyere N.   +4 more
europepmc   +1 more source

Sensitivity and specificity of the neutrophil-to-lymphocyte ratio for predicting mortality in patients with non-metastatic acral melanoma. [PDF]

JAAD Int
Pallares CNC, Sánchez Cárdenas CD, Guzmán ZER, Castillo G, Velázquez EG, Pulido Díaz N.   +5 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Error in Sensitivity and Specificity Estimates

JAMA Pediatrics, 2017
openaire   +3 more sources