IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He+5 more
wiley +1 more source
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls+9 more
wiley +1 more source
Artificial intelligence in hospital infection prevention: an integrative review. [PDF]
El Arab RA+4 more
europepmc +1 more source
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy+14 more
wiley +1 more source
Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy
Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers+7 more
wiley +1 more source
Notes from the Field: Suspected Medetomidine Withdrawal Syndrome Among Fentanyl-Exposed Patients - Philadelphia, Pennsylvania, September 2024-January 2025. [PDF]
Huo S+10 more
europepmc +1 more source
Discussion: “Sensitivity in Multivariable Control Systems” (Horton, W. F., and Leondes, C. T., 1969, ASME J. Basic Eng., 91, pp. 246–249) [PDF]
D. P. Lindorff
openalex +1 more source
Identification of inhibitors of the Salmonella FraB deglycase, a drug target
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law+6 more
wiley +1 more source
Implementation of Chaotic Synchronization and Artificial Neural Networks in Modified OTP Scheme for Image Encryption. [PDF]
Stoycheva H+3 more
europepmc +1 more source