Results 61 to 70 of about 926,309 (268)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Sensitivity Function Methods in Control System Education *

IFAC Proceedings Volumes, 1991
Abstract Parametric dependence of system responses is an important issue in control system analysis and design. Time domain sensitivity functions provide an efficient, simple and insightful method for evaluating parameters effects. Sensitivity function methods are reviewed, and a testbed arc welding installation is used to demonstrate the ...
W.R. Perkins, P.V. Kokotović, T. Bourrer, J.L. Schiano   +3 more
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Chaos in Control Systems: A Review of Suppression and Induction Strategies with Industrial Applications

Mathematics
In control systems, chaos is a natural dualistic phenomenon that can be both a beneficial resource to be used and a negative phenomenon to be avoided. The study examines two opposing paradigms: positive chaotic control, which aims to enhance performance,
Asad Shafique, Georgii Kolev, Oleg Bayazitov, Yulia Bobrova, Ekaterina Kopets   +4 more
doaj   +1 more source

Adaptive Coordination of Damping Controllers for Enhanced Power System Stability

IEEE Open Access Journal of Power and Energy, 2020
This paper introduces the concept of adaptive coordination of damping controllers for enhancing power system stability. The coordination uses phasor measurement units (PMUs) to adapt to different disturbances by selecting the switching status (on/off) of
Horacio Silva-Saravia, Hector Pulgar-Painemal, David A. Schoenwald, Wenyun Ju   +3 more
doaj   +1 more source

Improving system sensitivity via surplus controller capacity [PDF]

Journal of the Franklin Institute, 1966
Abstract In this paper a linear plant with variable characteristics is considered. It is assumed that the plant is driven optimally by an open-loop controller. For a particular task and a nominal plant characteristic the controller is assumed to have a surplus capacity (in the optimal sense).
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Review of Research on Voltage Dependent Current Order Limiter for Commutation Failure Mitigation [PDF]

Dianli jianshe
[Objective] The objective of this study is to systematically sort out the research status of the voltage dependent current order limiter（VDCOL）improvement method to enhance the ability of VDCOL control to commutation failure in high-voltage direct ...
ZHU Xuan, TANG Yi, ZHENG Chenyi, WANG Ying, DANG Jie, CUI Ting
doaj   +1 more source