Results 61 to 70 of about 899,236 (314)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Sensitivity driven experimental design to facilitate control of dynamical systems [PDF]

, 2022
Joseph Hart, Bart van Bloemen Waanders, Lisa Hood, Julie Parish   +3 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Sensitivity Function Methods in Control System Education *

IFAC Proceedings Volumes, 1991
Abstract Parametric dependence of system responses is an important issue in control system analysis and design. Time domain sensitivity functions provide an efficient, simple and insightful method for evaluating parameters effects. Sensitivity function methods are reviewed, and a testbed arc welding installation is used to demonstrate the ...
W.R. Perkins, P.V. Kokotović, T. Bourrer, J.L. Schiano   +3 more
openaire   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Chaos in Control Systems: A Review of Suppression and Induction Strategies with Industrial Applications

Mathematics
In control systems, chaos is a natural dualistic phenomenon that can be both a beneficial resource to be used and a negative phenomenon to be avoided. The study examines two opposing paradigms: positive chaotic control, which aims to enhance performance,
Asad Shafique, Georgii Kolev, Oleg Bayazitov, Yulia Bobrova, Ekaterina Kopets   +4 more
doaj   +1 more source

Adaptive Coordination of Damping Controllers for Enhanced Power System Stability

IEEE Open Access Journal of Power and Energy, 2020
This paper introduces the concept of adaptive coordination of damping controllers for enhancing power system stability. The coordination uses phasor measurement units (PMUs) to adapt to different disturbances by selecting the switching status (on/off) of
Horacio Silva-Saravia, Hector Pulgar-Painemal, David A. Schoenwald, Wenyun Ju   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Improving system sensitivity via surplus controller capacity [PDF]

Journal of the Franklin Institute, 1966
Abstract In this paper a linear plant with variable characteristics is considered. It is assumed that the plant is driven optimally by an open-loop controller. For a particular task and a nominal plant characteristic the controller is assumed to have a surplus capacity (in the optimal sense).
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source