Results 81 to 90 of about 2,663,215 (302)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Chaos in Control Systems: A Review of Suppression and Induction Strategies with Industrial Applications

Mathematics
In control systems, chaos is a natural dualistic phenomenon that can be both a beneficial resource to be used and a negative phenomenon to be avoided. The study examines two opposing paradigms: positive chaotic control, which aims to enhance performance,
Asad Shafique, Georgii Kolev, Oleg Bayazitov, Yulia Bobrova, Ekaterina Kopets   +4 more
doaj   +1 more source

Control of Integrable Hamiltonian Systems and Degenerate Bifurcations

, 2004
We discuss control of low-dimensional systems which, when uncontrolled, are integrable in the Hamiltonian sense. The controller targets an exact solution of the system in a region where the uncontrolled dynamics has invariant tori.
C. W. Kulp, E. R. Tracy, H. Goldstein, I. Percival, J. Guckenheimer, J. Lega, R. Ortega, S. Wiggins, Y. Li   +8 more
core   +1 more source

Improving system sensitivity via surplus controller capacity [PDF]

Journal of the Franklin Institute, 1966
Abstract In this paper a linear plant with variable characteristics is considered. It is assumed that the plant is driven optimally by an open-loop controller. For a particular task and a nominal plant characteristic the controller is assumed to have a surplus capacity (in the optimal sense).
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

An Easily Understandable Grey Wolf Optimizer and Its Application to Fuzzy Controller Tuning

Algorithms, 2017
This paper proposes an easily understandable Grey Wolf Optimizer (GWO) applied to the optimal tuning of the parameters of Takagi-Sugeno proportional-integral fuzzy controllers (T-S PI-FCs). GWO is employed for solving optimization problems focused on the
Radu-Emil Precup, Radu-Codrut David, Alexandra-Iulia Szedlak-Stinean, Emil M. Petriu, Florin Dragan   +4 more
doaj   +1 more source

Apollo experience report: Flight-control data needs, terminal display devices, and ground system configuration requirements [PDF]

The development of flight-control facilities for the Apollo program is reviewed from the viewpoint of the user organization. These facilities are treated in three categories: data systems, ground-based display and control systems, and configuration ...
Hoover, R. A.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

THE MODELLING OF ELECTRIC POWER SYSTEMS ON THE STATE SPACE AND CONTROLLING OF OPTIMAL LQR LOAD FREQUENCY

Electrica, 2009
The modelling of electric power systems on the state space and an optimal control system known as Linear Quadratic Regulator (LQR) for designing the load frequency control system are realized in this paper. In order to obtain high quality electric energy
ADNAN KAKİLLİ, YUKSEL OGUZ, HÜSEYİN ÇALIK   +2 more
doaj   +2 more sources