Results 81 to 90 of about 1,044,965 (267)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Centralized Hybrid Voltage Control of Active Distribution Network Using Recursive Least Squares Method for Sensitivity Estimation

IEEE Access
This paper presents a hybrid centralized, optimal, adaptive, and data-driven Volt-VAR and Volt-Watt control framework for voltage regulation in distribution systems. The proposed methodology coordinates on-load tap changers (OLTC), distributed generation
Mohammad Razeghi-Jahromi, Shadrack T. Asiedu, Moein Choobineh, Amanuel Melese   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Improved differential protection method for flexible low-frequency transmission system based on additional current compensation

International Journal of Electrical Power & Energy Systems
Low-frequency transmission systems (LFTS) emerge as a competitive solution to the problem of long-distance offshore wind transmission. Because the control strategy on both sides of the line will affect the phase and amplitude characteristics of the fault
Junjie Hou, Jingjing Cao, Yanfang Fan, Guobing Song, Xiaofang Wu   +4 more
doaj   +1 more source

Sensitivity Analysis of Uniform Control Systems

Uniform control systems, that is multivariable control systems with identical transfer functions of separate channels and rigid cross-connections, are widespread in modern industry and technology, including such fields as mechatronics and robotics, electrical and aerospace engineering, chemical and power industry, and many others.
Oleg Nikolay Gasparyan, Nerses Nersisyan, Haykanush Darbinyan, Ovsanna Ohanyan, Mariam Darakhchyan, Vahan Manukyan, Mkrtich Harutyunyan, Davit Danielyan   +7 more
openaire   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

SVC Control Strategy for Transient Stability Improvement of Multimachine Power System

Energies
The increase in renewable energy sources (RESs) in power systems is causing significant changes in their dynamic behavior. To ensure the safe operation of these systems, it is necessary to develop new methods for preserving transient stability that ...
Anica Šešok, Ivica Pavić
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source