Results 91 to 100 of about 2,663,215 (302)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Review of Research on Voltage Dependent Current Order Limiter for Commutation Failure Mitigation [PDF]

Dianli jianshe
[Objective] The objective of this study is to systematically sort out the research status of the voltage dependent current order limiter（VDCOL）improvement method to enhance the ability of VDCOL control to commutation failure in high-voltage direct ...
ZHU Xuan, TANG Yi, ZHENG Chenyi, WANG Ying, DANG Jie, CUI Ting
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Application of a sensitivity analysis technique to high-order digital flight control systems [PDF]

A sensitivity analysis technique for multiloop flight control systems is studied. This technique uses the scaled singular values of the return difference matrix as a measure of the relative stability of a control system.
Downing, David R., Paduano, James D.
core   +1 more source

Atom chips with two-dimensional electron gases: theory of near surface trapping and ultracold-atom microscopy of quantum electronic systems

, 2011
We show that current in a two-dimensional electron gas (2DEG) can trap ultracold atoms $
B. Kaczmarek, G. Sinuco-León, P. Krüger, R. Folman, T. M. Fromhold   +4 more
core   +1 more source

A Study on Zero Sensitive Control System

IEEJ Transactions on Electronics, Information and Systems, 2009
Since system uncertainties are unavoidable in the modeling, control systems are generally required to be insensitive to these uncertainties. In this paper, the problem of control system design which is insensitive to these uncertainties is studied, and a structure of system uncertainties which do not affect the control performance is clarified.
Katsuhiko Fuwa, Tatsuo Narikiyo, Hisashi Kando   +2 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Centralized Hybrid Voltage Control of Active Distribution Network Using Recursive Least Squares Method for Sensitivity Estimation

IEEE Access
This paper presents a hybrid centralized, optimal, adaptive, and data-driven Volt-VAR and Volt-Watt control framework for voltage regulation in distribution systems. The proposed methodology coordinates on-load tap changers (OLTC), distributed generation
Mohammad Razeghi-Jahromi, Shadrack T. Asiedu, Moein Choobineh, Amanuel Melese   +3 more
doaj   +1 more source