Results 61 to 70 of about 986,843 (218)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Chaos in Control Systems: A Review of Suppression and Induction Strategies with Industrial Applications

Mathematics
In control systems, chaos is a natural dualistic phenomenon that can be both a beneficial resource to be used and a negative phenomenon to be avoided. The study examines two opposing paradigms: positive chaotic control, which aims to enhance performance,
Asad Shafique, Georgii Kolev, Oleg Bayazitov, Yulia Bobrova, Ekaterina Kopets   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

THE MODELLING OF ELECTRIC POWER SYSTEMS ON THE STATE SPACE AND CONTROLLING OF OPTIMAL LQR LOAD FREQUENCY

Electrica, 2009
The modelling of electric power systems on the state space and an optimal control system known as Linear Quadratic Regulator (LQR) for designing the load frequency control system are realized in this paper. In order to obtain high quality electric energy
ADNAN KAKİLLİ, YUKSEL OGUZ, HÜSEYİN ÇALIK   +2 more
doaj   +2 more sources

An Easily Understandable Grey Wolf Optimizer and Its Application to Fuzzy Controller Tuning

Algorithms, 2017
This paper proposes an easily understandable Grey Wolf Optimizer (GWO) applied to the optimal tuning of the parameters of Takagi-Sugeno proportional-integral fuzzy controllers (T-S PI-FCs). GWO is employed for solving optimization problems focused on the
Radu-Emil Precup, Radu-Codrut David, Alexandra-Iulia Szedlak-Stinean, Emil M. Petriu, Florin Dragan   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

An approach to the LQG/LTR design problem with specifications for finite-dimensional SISO control systems

Systems Science & Control Engineering
This is an expository paper that discusses an approach to the linear quadratic Gaussian/loop transfer recovery (LQG/LTR) design problem for finite-dimensional single-variable (single-input/single-output, SISO) control systems.
Mahyar Mahinzaeim, Kamyar Mehran
doaj   +1 more source

Optimal Control for One-Qubit Quantum Sensing

Physical Review X, 2018
Quantum systems can be exquisite sensors thanks to their sensitivity to external perturbations. This same characteristic also makes them fragile to external noise. Quantum control can tackle the challenge of protecting a quantum sensor from environmental
F. Poggiali, P. Cappellaro, N. Fabbri
doaj   +1 more source