Results 121 to 130 of about 1,129,627 (263)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A two-stages global sensitivity analysis by using the δ sensitivity index in presence of correlated inputs: application on a tumor growth inhibition model based on the dynamic energy budget theory. [PDF]

J Pharmacokinet Pharmacodyn, 2023
De Carlo A, Tosca EM, Melillo N, Magni P.   +3 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The relationships between FLAIS, a novel insulin sensitivity index, and cardiovascular risk factors in a population-based study. [PDF]

Cardiovasc Diabetol, 2022
Karczewska-Kupczewska M, Nikołajuk A, Kondraciuk M, Stachurska Z, Dubatówka M, Szpakowicz A, Strączkowski M, Kowalska I, Kamiński K.   +8 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Sensitivity to Data Choice for Index‐Based Flood Insurance

Earth's Future
Despite increasing adoption of earth observations data to inform disaster response and recovery, deciding which measurements to use—and how—remains an open question.
Alex Saunders, Beth Tellman, Elinor Benami, Kevin Anchukaitis, Sazzad Hossain, Andrew Bennett, A. K. M. Saiful Islam, Jonathan Giezendanner   +7 more
doaj   +1 more source

Development and Initial Validation of the Relaxation Sensitivity Index. [PDF]

Int J Cogn Ther, 2021
Luberto CM, McLeish AC, Kallen RW.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Minimizing power loss in radial power distribution networks via optimal DG allocation using sensitivity indices aided hippopotamus optimization algorithm

Scientific Reports
This paper introduces a new hybrid approach for efficiently optimizing the placement and sizing of DG units in the radial distribution power network (RDPN) by combining the loss sensitivity index (LSI) and voltage sensitivity index (VSI) with a novel ...
P Rajakumar, D Ashokaraju, M Senthil Kumar, J Chandramohan, D Thangaraj, P Sabarish, Eric Sylvester Mwanandiye   +6 more
doaj   +1 more source

A Novel Fragmentation Sensitivity Index Determines the Susceptibility of Red Blood Cells to Mechanical Trauma. [PDF]

Front Physiol, 2021
Ugurel E, Goksel E, Goktas P, Cilek N, Atar D, Yalcin O.   +5 more
europepmc   +1 more source