Results 121 to 130 of about 6,464,851 (305)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
GeopautaConcept of climate-smart forestry, designed for mountain forests, was modified and applied to urban forest areas which are under high anthropogenic and climate change pressures.
Milica Kašanin-Grubin +5 more
doaj +1 more source
, 1933 This is the College of Wooster Index from 1933. At the beginning of this Index, there are numerous pictures of all of the buildings on campus. The rest of the publication is divided into multiple sections including administration, faculty, students ...
Index Editors,
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Translation and validation of the Ukrainian version of the visceral sensitivity index for patients with irritable bowel syndrome. [PDF]
Prz Gastroenterol, 2023 Neverovskyi A, Shypulin V, Mikhnova N.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Factor structure of the anxiety sensitivity index-3 in a sample of older adults. [PDF]
Eur J Ageing, 2022 Robinson A, Weitzner DS, Calamia M.
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Assisted reproductive technology and interactions between serum basal FSH/LH and ovarian sensitivity index. [PDF]
Front Endocrinol (Lausanne), 2023 He Y +7 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source