Results 101 to 110 of about 2,233,236 (246)
IEEE Photonics Journal, 2017 Low current sensitivity and insufficient system robustness are two significant obstacles preventing widespread use of all-fiber current sensors (AFCSs). We demonstrate a novel AFCS combining a fiber-loop architecture and a reflection scheme.
Hao Zhang
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
A method for increasing the robustness of multiple imputation [PDF]
, 2012 Missing data are common wherever statistical methods are applied in practice. They present a problem in that they require that additional assumptions be made about the mechanism leading to the incompleteness of the data.
Kenward, Michael G. +5 more
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
StabilEdge, Formal Verification of Edge AI Applications
IEEE AccessThis paper addresses the critical need for AI trustworthiness in smart IoT systems by focusing on the stability of Deep Neural Networks (DNNs) in Edge AI. State-of-the-art model checkers guarantee feasibility of a single stability analysis.
Luca Lazzaroni +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Robustness versus efficiency for nonparametric correlation measures. [PDF]
Nonparametric correlation measures at the Kendall and Spearman correlation are widely used in the behavioral sciences. These measures are often said to be robust, in the sense of being resistant to outlying observations.
Croux, Christophe, Dehon, Catherine
core
Reli fadianWith the grid-connection of renewable energy systems, more coal-fired units are required to participate in deep-peak-shaving and quickly respond to the automatic generation control command.
SHI Gengjin, WU Zhenlong
doaj +1 more source