Results 101 to 110 of about 2,734,080 (302)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

BAYESIAN ANALYSIS OF THE COMPOUND COLLECTIVE MODEL; THE VARIANCE PREMIUM PRINCIPLE WITH EXPONENTIAL POISSON AND GAMMA-GAMMA DISTRIBUTIONS [PDF]

open access: yes
The distribution of the aggregate claim size is the considerable importance in insurance theory since, for example, it is needed as an input in premium calculation principles and reserve calculation which plays an important paper in ruin theory.
E. Gómez-Deniz   +2 more
core  

EPS Current Tracking Method Research Based on Hybrid Sensitivity H∞ Control Algorithm

open access: yesJournal of Electrical and Computer Engineering, 2018
For electric power steering system (EPS), road interference, noise of the sensor, and the uncertainty of the steering system may make EPS control effect and the driver's road sense worse. EPS system which takes advantage of good current tracking ability,
Hairong Wu   +6 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Revisiting the Basis of Sensitivity Analysis for Dynamical Earth System Models

open access: yesWater Resources Research, 2018
This paper investigates the problem of global sensitivity analysis (GSA) of Dynamical Earth System Models and proposes a basis for how such analyses should be performed.
Hoshin V. Gupta, Saman Razavi
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Robustness of infinite dimensional systems [PDF]

open access: yes
The results contained within this thesis concern an abstract framework for a robustness analysis of exponential stability of infinite dimensional systems.
Townley, Stuart
core  

The effect of block parameter perturbations in Gaussian Bayesian networks: Sensitivity and robustness

open access: yes, 2013
n this work we study the effects of model inaccuracies on the description of a Gaussian Bayesian network with a set of variables of interest and a set of evidential variables.
Gómez Villegas, Miguel Ángel   +2 more
core   +1 more source

High Temperature and Vibration Robustness All-Fiber Current Sensor With a Fiber-Loop Architecture and Reflection Scheme

open access: yesIEEE Photonics Journal, 2017
Low current sensitivity and insufficient system robustness are two significant obstacles preventing widespread use of all-fiber current sensors (AFCSs). We demonstrate a novel AFCS combining a fiber-loop architecture and a reflection scheme.
Hao Zhang
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

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