Results 81 to 90 of about 361,200 (307)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Robustness of dynamic quantum control: Differential sensitivity bounds [PDF]
Dynamic control via optimized, piecewise-constant pulses is a common paradigm for open-loop control to implement quantum gates. While numerous methods exist for the synthesis of such controls, there are many open questions regarding the robustness of the
Sophie Shermer
core +3 more sources
A Comparative Study of UCB and Thompson Sampling with Structured Rewards: Parameter Sensitivity and Robustness [PDF]
ITM Web of ConferencesThe behavior of multi-armed bandit (MAB) algorithms is closely tied to how their hyperparameters are set, but their stability in structured reward environments has not been examined in depth.
Chen Yutong
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
AnimalProduction animals are increasingly exposed to a wide variety of disturbances that can compromise their productivity, health and well-being. As a result, there is a growing need to be able to select animals that are more resilient to environmental ...
E.G. Smith, S.F. Walkom, S.A. Clark
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Geometric Interpretation of Frequency Domain Robustness Constraints and Closed-Loop Pole Locations
MathematicsRequirements for robustness and performance in the frequency domain in control theory are usually formulated as constraints on the modulus of complex functions describing the open-loop system, the sensitivity function, and the complementary sensitivity ...
Vesela Karlova-Sergieva
doaj +1 more source
EPS Current Tracking Method Research Based on Hybrid Sensitivity H∞ Control Algorithm
Journal of Electrical and Computer Engineering, 2018 For electric power steering system (EPS), road interference, noise of the sensor, and the uncertainty of the steering system may make EPS control effect and the driver's road sense worse. EPS system which takes advantage of good current tracking ability,
Hairong Wu +6 more
doaj +1 more source
Extended Sensitivity Analysis for Applied General Equilibrium Models [PDF]
Previous sensitivity analysis procedures for applied general equilibrium models have focussed on the values of exogenously assigned elasticity parameters, while the calibrated parameters -those that are obtained from combining elasticity information with
Christina Dawkins
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source