Results 61 to 70 of about 2,233,236 (246)

Assessing the robustness and implications of econometric estimates of climate sensitivity

Environmental Research Letters
Earth’s transient climate response (TCR) quantifies the global mean surface air temperature change due to a doubling of atmospheric $\mathrm{CO_2}$ concentration after 70 years of a compounding 1% per year increase.
Trude Storelvmo, Menghan Yuan, Thomas Leirvik, Kari Alterskjær, Peter C B Phillips, Chris Smith   +5 more
doaj   +1 more source

How robust are findings of pairwise and network meta-analysis in the presence of missing participant outcome data?

BMC Medicine, 2021
Background To investigate the prevalence of robust conclusions in systematic reviews addressing missing (participant) outcome data via a novel framework of sensitivity analyses and examine the agreement with the current sensitivity analysis standards ...
Loukia M. Spineli, Chrysostomos Kalyvas, Katerina Papadimitropoulou   +2 more
doaj   +1 more source

A comparative study of energy graph-based fault detection and isolation techniques applied to a lignite plant

Heliyon, 2023
Energy and exergy interactions in industrial systems hold meaning across physical domains. This paper builds on the notion that capturing the energy and exergy interactions of a system, while retaining physical structural context, enables fault detection
Jan Hendrik Smith, George van Schoor, Kenneth R. Uren, Martin van Eldik, Frank Worlitz   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Robustness and sensitivity metrics-based tuning of the augmented Kalman filter for single-channel speech enhancement

, 2021
The inaccurate estimates of the speech and noise linear prediction coefficients (LPCs) introduce bias in augmented Kalman filter (AKF) gain, which impacts the quality and intelligibility of enhanced speech. Although current tuning methods offset the bias
Roy, Sujan Kumar, Paliwal, Kuldip K
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Robust and Sensitive Analysis of Mouse Knockout Phenotypes

PLoS ONE, 2012
A significant challenge of in-vivo studies is the identification of phenotypes with a method that is robust and reliable. The challenge arises from practical issues that lead to experimental designs which are not ideal. Breeding issues, particularly in the presence of fertility or fecundity problems, frequently lead to data being collected in multiple ...
Natasha A Karp, David Melvin, Sanger Mouse Genetics Project, Richard F Mott   +3 more
openaire   +3 more sources