Results 61 to 70 of about 789,696 (298)
Experimental and bond graph based sensitivity calculations for micro-scale robust engineering design [PDF]
, 2005 Copyright @ 2005 IEEEBond graph modeling and sensitivity analysis are used to provide a platform for the robust design of a small mechatronic device, a behind-the-ear (BTE) hearing aid.
Atherton, MA +5 more
core
Law of localization in chemical reaction networks
, 2016 In living cells, chemical reactions are connected by sharing their products and substrates, and form complex networks, e.g. metabolic pathways. Here we developed a theory to predict the sensitivity, i.e.
Mochizuki, Atsushi, Okada, Takashi
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Assessing the robustness and implications of econometric estimates of climate sensitivity
Environmental Research LettersEarth’s transient climate response (TCR) quantifies the global mean surface air temperature change due to a doubling of atmospheric $\mathrm{CO_2}$ concentration after 70 years of a compounding 1% per year increase.
Trude Storelvmo +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Comparative and qualitative robustness for law-invariant risk measures
, 2014 When estimating the risk of a P&L from historical data or Monte Carlo simulation, the robustness of the estimate is important. We argue here that Hampel's classical notion of qualitative robustness is not suitable for risk measurement and we propose and ...
Krätschmer, Volker +2 more
core +1 more source
Robust Classification with Context-Sensitive Features
, 1993 This paper addresses the problem of classifying observations when features are context-sensitive, especially when the testing set involves a context that is different from the training set. The paper begins with a precise definition of the problem, then general strategies are presented for enhancing the performance of classification algorithms on this ...
openaire +4 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source