Results 41 to 50 of about 789,696 (298)

The Influence of Canalization on the Robustness of Boolean Networks

, 2016
Time- and state-discrete dynamical systems are frequently used to model molecular networks. This paper provides a collection of mathematical and computational tools for the study of robustness in Boolean network models.
Albert, Balleza, Boccaletti, Boppana, C. Kadelka, Cook, Davidich, Derrida, Derrida, Dimitrova, Drossel, Fretter, He, J. Kuipers, Jansen, Jarrah, Karlsson, Kauffman, Kauffman, Kauffman, Kauffman, Kauffman, Kitano, Kochi, Layne, Li, Li, Liu, Marques-Pita, Murrugarra, Murrugarra, Nykter, R. Laubenbacher, Shmulevich, Shmulevich, Strogatz, Thomas, Waddington   +37 more
core   +1 more source

Sensitivity Gains by Mismatched Probabilistic Shaping for Optical Communication Systems [PDF]

, 2015
Probabilistic shaping of quadrature amplitude modulation (QAM) is used to enhance the sensitivity of an optical communication system. Sensitivity gains of 0.43 dB and 0.8 dB are demonstrated in back-to-back experiments by shaping of 16QAM and 64QAM ...
Alvarado, Alex, Bayvel, Polina, Fehenberger, Tobias, Hanik, Norbert, Lavery, Domaniç, Maher, Robert   +5 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Design of a microelectromechanical systems resonant electric field sensor with sensitivity robustness

Advances in Mechanical Engineering, 2015
Studies indicate that driving circuit and drift error in resonance frequency influence the sensitivity of micromechanical resonant electric field sensors. This study proposes an electric field sensor with a comb structure for driving and sensing.
Heng Liu, Jia-qi Xu, Feng Xiong, Rui-li Meng   +3 more
doaj   +1 more source

Robustness of the Thirty Meter Telescope Primary Mirror Control System [PDF]

, 2010
The primary mirror control system for the Thirty Meter Telescope (TMT) maintains the alignment of the 492 segments in the presence of both quasi-static (gravity and thermal) and dynamic disturbances due to unsteady wind loads.
MacMynowski, Douglas G., Roberts, Lewis C., Shelton, Chris, Thompson, Peter M.   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The impact of FASTQ and alignment read order on structural variant calling from long-read sequencing data [PDF]

PeerJ
Background Structural variant (SV) calling from DNA sequencing data has been challenging due to several factors, including the ambiguity of short-read alignments, multiple complex SVs in the same genomic region, and the lack of “truth” datasets for ...
Kyle J. Lesack, James D. Wasmuth
doaj   +2 more sources

How robust are findings of pairwise and network meta-analysis in the presence of missing participant outcome data?

BMC Medicine, 2021
Background To investigate the prevalence of robust conclusions in systematic reviews addressing missing (participant) outcome data via a novel framework of sensitivity analyses and examine the agreement with the current sensitivity analysis standards ...
Loukia M. Spineli, Chrysostomos Kalyvas, Katerina Papadimitropoulou   +2 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Sensitivity Analysis of Evolutionary Algorithm for Software Reusability

Mendel, 2019
Fast and competitive software industry demands rapid development using Component Based Software Development (CBSD).  CBSD is dependent on the availability of the high-quality reusable component libraries.
Amit Rathee, Jitender Kumar Chhabra
doaj   +1 more source