Results 141 to 150 of about 86,685,215 (261)

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

LXRα and PPARα Mediated Hepatic Lipid Metabolic Disruption Induced by the UV Filter EHMC in 2D and 3D HepaRG Cell Models

Food Safety and Health, EarlyView.
Dietary UV filter EHMC induces hepatic steatosis in HepaRG cells at noncytotoxic concentrations. Mechanistically, EHMC binds nuclear receptors (LXRα, PPARα), upregulating SREBP‐1 to accelerate fatty acid synthesis. These findings highlight the potential metabolic toxicity of widespread EHMC exposure through food sources.
Shanglin Yang, Na Li, Yingnan Han, Mei Ma   +3 more
wiley   +1 more source

Role of Twist1 transcription factor in thyroid tumor progression [PDF]

, 2011
Thyroid carcinomas are the most common endocrine tumors in humans, with a globally increasing incidence. Differentiated tumors, such as papillary (PTC) and follicular (FTC) thyroid cancers, are often curable with surgical resection and radiotherapy ...
Bencivenga, Tammaro Claudio
core  

Treatment‐Related Adverse Events and Health‐Related Quality of Life Associated With Immune Checkpoint Inhibitor Treatment for Mucosal Head and Neck Squamous Cell Carcinoma: A Scoping Review

Head &Neck, EarlyView.
ABSTRACT Background Supportive care needs of patients receiving immune checkpoint inhibitors (ICIs) for head and neck squamous cell carcinoma (HNSCC) are ill‐defined. Hence, known treatment‐related adverse events (TRAEs) and health‐related quality of life (HRQoL) associated with ICI treatment for HNSCC were examined to inform future supportive care ...
N. D. O'Donnell, E. C. Ward, L. R. Wishart, R. Perera, C. Barrett, K. A. Edmiston, E. Mitchell, A. Pigott, R. Pitt, K. Russell, B. A. Chan, R. Ladwa   +11 more
wiley   +1 more source

Clinical, Radiologic and Cytologic Predictors of Malignancy in Pediatric Thyroid Nodules: Insights From a 26‐Year Cohort Study

Head &Neck, EarlyView.
ABSTRACT Introduction Thyroid nodules are less common but more often malignant in pediatric patients than in adults. Our objectives were to study the features of benign vs. malignant thyroid nodules in a large pediatric patient cohort. Methods Retrospective observational cohort study. Consecutive patients aged 0.01–17.9 years at evaluation between 1997–
Maxime Gest‐Laurent, Adrien Nguyen Quoc, Christine Lefevre, Laura González‐Briceño, Caroline Thalassinos, Isabelle Flechtner, Dulanjalee Kariyawasam, Yamina Dassa, Magali Viaud, Dinane Samara‐Boustani, Graziella Pinto, Hervé Monpeyssen, Sabine Sarnacki, Vincent Couloigner, Michel Polak, Athanasia Stoupa   +15 more
wiley   +1 more source

Therapeutic strategies to target the receptor tyrosine kinase AXL in thyroid cancer

, 2012
The AXL receptor tyrosine kinase is overexpressed and active in various cancer types including thyroid carcinoma, and several preclinical studies suggest that targeting AXL is an effective therapeutical strategy in AXL-positive cancers.
MELILLO, ROSA MARINA, GnanaPrakasam Krisnamoorthy, VISCIANO, CARLA, CARLOMAGNO, Francesca, LIOTTI, FEDERICA, GUIDA, TERESA   +5 more
core  

Strain and Shear Wave Elastography in Thyroid Nodules: Tissue Stiffness as a Complementary Risk Marker for Differentiating Benign, Indeterminate, and Malignant Cytology

Head &Neck, EarlyView.
ABSTRACT Objective To evaluate the diagnostic performance of shear wave elastography (SWE) and strain elastography (SE) as complementary techniques to conventional B‐mode ultrasound for differentiating benign, indeterminate, and malignant thyroid nodules. Methods This prospective cross‐sectional study included 208 thyroid nodules evaluated using B‐mode
Kairo Alexandre Alves Silveira, Icleia Siqueira Barreto, Ilka Mara Borges Botelho, Elizabeth João Pavin, Ademar Yamanaka, Denise Engelbrecht Zantut‐Wittmann   +5 more
wiley   +1 more source

Why do national IDD control programmes fail : case studies from Indo-China

, 2014
Iodine is a trace element and is responsible for the synthesis of thyroid hormones that are critical for brain development especially in the foetal and early childhood development1.
Ma, Gary (R17095)
core  

Development and Preliminary Validation of a Modified Thyroid Symptom Questionnaire (TSQ)

Head &Neck, EarlyView.
ABSTRACT Background This study aimed to modify and validate the Thyroidectomy Voice and Symptom Questionnaire (TVSQ) to serve as a symptom screening tool in benign thyroid disease. Methods A 32‐item modified TVSQ was developed and administered alongside a symptom checklist to outpatients; controls were recruited to determine discriminative validity ...
Vikash Yogaraj, Debra Phyland, Catherine Sinclair   +2 more
wiley   +1 more source

A case report: Diagnosis and treatment of idiopathic hypertrophic pachymeningitis

Ibrain, Volume 11, Issue 1, Page 112-116, Spring 2025.
We reported a case of idiopathic hypertrophic dura meningitis diagnosed in our hospital. The patient repeatedly suffered from headaches, followed by blurred vision in the right eye. During this period, multiple sclerosis was considered for diagnosis, and it improved after hormone treatment.
Zhong Luo, Piao Cao, Jing‐Qing Xu, Rong Yan, Jian Wang, Tao Liang, Ya Chen, Zu‐Cai Xu   +7 more
wiley   +1 more source