Results 1 to 10 of about 2,494,794 (173)

Association between central thyroid hormone sensitivity and prediabetes: Tehran thyroid study [PDF]

Frontiers in Endocrinology
BackgroundThyroid hormone sensitivity indices represent a recently proposed clinical entity related to metabolic health outcomes. The link between thyroid hormone sensitivity and prediabetes is not clear.
Ladan Mehran, Mohammadjavad Honarvar, Maryam Tohidi, Maryam Adib, Fereidoun Azizi, Atieh Amouzegar   +5 more
doaj   +6 more sources

Sensitivity to thyroid hormone indices are associated with papillary thyroid carcinoma in Chinese patients with thyroid nodules

BMC Endocrine Disorders, 2023
Background The association between thyroid hormone sensitivity and thyroid cancer is unknown, and we aimed to investigate the association between sensitivity to thyroid hormone indices and papillary thyroid carcinoma (PTC) in Chinese patients with ...
Jie Sun, Jie Liu, Ting-ting Wu, Zhi-yuan Gu, Xiao-wen Zhang   +4 more
doaj   +4 more sources

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor α [PDF]

Proceedings of the National Academy of Sciences, 2000
Only three of the four thyroid hormone receptor (TR) isoforms, α1, β1, and β2, bind thyroid hormone (TH) and are considered to be true TRs. TRα2 binds to TH response elements on DNA, but its role in vivo is still unknown. We produced mice completely deficient in TRα (TRα
Macchia, P.E., Takeuchi, Y., Kawai, Tadashi, Cua, K., Gauthier, Karine, Chassande, O., Seo, H., Hayashi, Y., Samarut, Jacques, Murata, Y., Weiss, R.E., Refetoff, S.   +11 more
openaire   +8 more sources

Reduced sensitivity to thyroid hormones is associated with differentiated thyroid cancer in the euthyroid thyroidectomy population

Frontiers in Endocrinology
BackgroundThe inconclusive associations between thyroid-related hormones and differentiated thyroid cancer (DTC) suggest complex pathophysiologic processes, for which thyroid hormone sensitivity may provide new insights.MethodsWe retrospectively analyzed
Huaijin Xu, Huaijin Xu, Hongzhou Liu, Xiaodong Hu, Xiaomeng Jia, Zhe Xue, Anning Wang, Shaoyang Kang, Shaoyang Kang, Zhaohui Lyu, Zhaohui Lyu   +10 more
doaj   +3 more sources

Reduced Sensitivity to Thyroid Hormone Is Associated with Diabetes and Hypertension [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2021
Abstract Context Recently, reduced sensitivity to thyroid hormone as a more common finding in the general population and its possible association with metabolic parameters has been the focus of attention.
Ladan Mehran, Negar Delbari, Atieh Amouzegar, Mitra Hasheminia, Maryam Tohidi, Fereidoun Azizi   +5 more
  +11 more sources

Iodothyronine deiodinases and reduced sensitivity to thyroid hormones [PDF]

Frontiers in Bioscience, 2020
Iodothyronine deiodinases are selenoproteins that regulate thyroid hormone metabolism. Of the three types of deiodinases, type 2 is the major regulator of intracellular triiodothyronine concentration in both the hypothalamus and pituitary, and therefore the major regulator of thyrotropin secretion. A defect in iodothyronine deiodinase activity can lead
Paragliola R. M., Corsello A., Concolino P., Ianni F., Papi G., Pontecorvi A., Corsello S. M.   +6 more
openaire   +5 more sources

Iodine deficiency is associated with increased thyroid hormone sensitivity in individuals with elevated TSH

European Thyroid Journal, 2023
Objective: Central sensitivity of thyroid hormone refers to the sensitivity of hypothalamic– pituitary–thyroid (HPT) axis to the change in circulating free thyroxine (fT4).
Ying Sun, Di Teng, Lei Zhao, Xiaoguang Shi, Yongze Li, Zhongyan Shan, Weiping Teng   +6 more
doaj   +1 more source

The syndromes of reduced sensitivity to thyroid hormone [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Six known steps are required for the circulating thyroid hormone (TH) to exert its action on target tissues. For three of these steps, human mutations and distinct phenotypes have been identified.The clinical, laboratory, genetic and molecular characteristics of these three defects of TH action are the subject of this review.
Alexandra M, Dumitrescu, Samuel, Refetoff   +1 more
openaire   +2 more sources

Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD [PDF]

Frontiers in Endocrinology, 2021
BackgroundPrevious studies on the association between thyroid function and non‐alcoholic fatty liver disease (NAFLD) have contradicted. Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivity to thyroid hormone indices with NAFLD.MethodsA ...
Shuiqing Lai, Jiarong Li, Jiarong Li, Zixiao Wang, Wei Wang, Haixia Guan   +5 more
openaire   +3 more sources

Higher Sensitivity to Thyroid Hormones May Be Linked to Maintaining the Healthy Metabolic Condition in People with Obesity: New Insight from NHANES

Obesity Facts, 2023
Introduction: Obesity contributes to the pathogenesis of diverse metabolic diseases, yet the mechanism underlying metabolically healthy obesity (MHO) remains elusive. Thyroid hormones and sensitivity to them have a major impact on metabolism.
Ying-shan Liu, Xiao-cong Liu, Jian Kuang, Hai-xia Guan   +3 more
doaj   +1 more source