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Impaired Sensitivity to Thyroid Hormone and Risk of Carotid Plaque Development in a Chinese Health Check-Up Population: A Large Sample Cross-Sectional Study

Diabetes, Metabolic Syndrome and Obesity
Jiangling Wang,1,2,* Lijuan Yang,3,* Wei Liu,1 Chaogang Wei,1 Junkang Shen1 1Department of Radiology, The Second Affiliated Hospital of Soochow University, Soochow, Jiangsu, People’s Republic of China; 2Department of Physical Diagnosis, Huadong ...
Wang J, Yang L, Liu W, Wei C, Shen J
doaj   +1 more source

Correlation between thyroid hormone sensitivity and the risk of polycystic ovary syndrome. [PDF]

BMC Endocr Disord
Objective There has been some confusion in earlier research on the connection between thyroid function and polycystic ovary syndrome (PCOS). This research is aimed to probe into the correlation between thyroid condition and the risk of PCOS from a new ...
Wang Q, Zhao R, Han C, Huang Z, Bi Y, Zhang X, Shen S.   +6 more
europepmc   +2 more sources

Longitudinal evidence of the impact of normal thyroid stimulating hormone variations on cognitive functioning in very old age [PDF]

, 2008
The purpose of this study was to examine longitudinal associations among thyroid stimulating hormone (TSH) levels and cognitive performance. Data collected at the first three assessment times, approximately 3 years apart, are reported for the survivors ...
Wahlin, TBR, Wahlin, A, Bunce, D
core   +6 more sources

Reduced Sensitivity to Thyroid Hormone Is Associated with Diabetes and Hypertension [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2021
Abstract Context Recently, reduced sensitivity to thyroid hormone as a more common finding in the general population and its possible association with metabolic parameters has been the focus of attention.
Ladan Mehran, Negar Delbari, Atieh Amouzegar, Mitra Hasheminia, Maryam Tohidi, Fereidoun Azizi   +5 more
  +11 more sources

Iodothyronine deiodinases and reduced sensitivity to thyroid hormones [PDF]

Frontiers in Bioscience, 2020
Iodothyronine deiodinases are selenoproteins that regulate thyroid hormone metabolism. Of the three types of deiodinases, type 2 is the major regulator of intracellular triiodothyronine concentration in both the hypothalamus and pituitary, and therefore the major regulator of thyrotropin secretion. A defect in iodothyronine deiodinase activity can lead
Paragliola R. M., Corsello A., Concolino P., Ianni F., Papi G., Pontecorvi A., Corsello S. M.   +6 more
openaire   +5 more sources

Iodine deficiency is associated with increased thyroid hormone sensitivity in individuals with elevated TSH

European Thyroid Journal, 2023
Objective: Central sensitivity of thyroid hormone refers to the sensitivity of hypothalamic– pituitary–thyroid (HPT) axis to the change in circulating free thyroxine (fT4).
Ying Sun, Di Teng, Lei Zhao, Xiaoguang Shi, Yongze Li, Zhongyan Shan, Weiping Teng   +6 more
doaj   +1 more source

The syndromes of reduced sensitivity to thyroid hormone [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Six known steps are required for the circulating thyroid hormone (TH) to exert its action on target tissues. For three of these steps, human mutations and distinct phenotypes have been identified.The clinical, laboratory, genetic and molecular characteristics of these three defects of TH action are the subject of this review.
Alexandra M, Dumitrescu, Samuel, Refetoff   +1 more
openaire   +2 more sources

Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD [PDF]

Frontiers in Endocrinology, 2021
BackgroundPrevious studies on the association between thyroid function and non‐alcoholic fatty liver disease (NAFLD) have contradicted. Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivity to thyroid hormone indices with NAFLD.MethodsA ...
Shuiqing Lai, Jiarong Li, Jiarong Li, Zixiao Wang, Wei Wang, Haixia Guan   +5 more
openaire   +3 more sources

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor α [PDF]

Proceedings of the National Academy of Sciences, 2000
Only three of the four thyroid hormone receptor (TR) isoforms, α1, β1, and β2, bind thyroid hormone (TH) and are considered to be true TRs. TRα2 binds to TH response elements on DNA, but its role in vivo is still unknown. We produced mice completely deficient in TRα (TRα
Macchia, P.E., Takeuchi, Y., Kawai, Tadashi, Cua, K., Gauthier, Karine, Chassande, O., Seo, H., Hayashi, Y., Samarut, Jacques, Murata, Y., Weiss, R.E., Refetoff, S.   +11 more
openaire   +6 more sources

Higher Sensitivity to Thyroid Hormones May Be Linked to Maintaining the Healthy Metabolic Condition in People with Obesity: New Insight from NHANES

Obesity Facts, 2023
Introduction: Obesity contributes to the pathogenesis of diverse metabolic diseases, yet the mechanism underlying metabolically healthy obesity (MHO) remains elusive. Thyroid hormones and sensitivity to them have a major impact on metabolism.
Ying-shan Liu, Xiao-cong Liu, Jian Kuang, Hai-xia Guan   +3 more
doaj   +1 more source