Results 41 to 50 of about 71,901 (277)

Resistance to thyroid hormone: one of several defects causing reduced sensitivity to thyroid hormone [PDF]

Nature Clinical Practice Endocrinology & Metabolism, 2008
Resistance to thyroid hormone: one of several defects causing reduced sensitivity to thyroid ...
openaire   +2 more sources

Impaired Sensitivity to Thyroid Hormones Is Associated With Elevated Blood Glucose in Coronary Heart Disease

Frontiers in Endocrinology, 2022
ContextThyroid hormones influence glucose homeostasis through central and peripheral regulation. To date, the association between thyroid hormone sensitivity and elevated blood glucose (EBG) in patients with coronary heart disease (CHD) remains unknown ...
Lu Yu, Zhu Li, Rongrong Yang, Guangwei Pan, Qi Cheng, Yuanyuan He, Yijia Liu, Fanfan Liu, Mei Ma, Tong Yang, Yang Wang, Jinyu Su, Yanchao Zheng, Shan Gao, Qiang Xu, Lin Li, Chunquan Yu   +16 more
doaj   +1 more source

Functional Sensitivity and Recovery of Thyroid-stimulating Hormone [PDF]

Clinical Chemistry, 2001
Comparisons of the Vitros ECi thyroid-stimulating hormone (TSH) method with the AxSym (1), Immulite (1)(2), Elecsys (2), and ADVIA Centaur (2) have shown an unexplained progressive negative bias
Martin Cruise, Ian Catch, Christine Burgin, Alun Price   +3 more
openaire   +1 more source

Involvement of the hypothalamic-pituitary-thyroid axis and its interaction with the hypothalamic-pituitary-adrenal axis in the ontogeny of avian thermoregulation: a review

, 2008
The emergence of thermoregulation in avian species is a complex matter in which neural as well as hormonal processes are involved. In a previous paper, the neural aspects of primary avian thermoregulation were discussed.
Brand, H., van den, Kemp, B., Bruggeman, V., Debonne, M., Decuypere, E., Baarendse, P.J.J.   +5 more
core   +1 more source

Thyroid Hormone Resistance Syndromes

, 2019
Syndromes with impaired sensitivity to thyroid hormone (TH) include three types of resistance to thyroid hormone (RTH) syndromes (RTHβ, RTHα, and nonTR-RTH) and also include patients with defects in TH transport into cells (thyroid hormone cell membrane ...
Refetoff, Samuel, Roy E. Weiss, Samuel Refetoff, Weiss, Roy E   +3 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Impaired Sensitivity to Thyroid Hormones is Associated with Mild Cognitive Impairment in Euthyroid Patients with Type 2 Diabetes

, 2023
Zi-Wei Yu,1,* Sheng-Dan Pu,2,* Xiao-Tong Sun,2 Xi-Chang Wang,1 Xin-Yuan Gao,2 Zhong-Yan Shan1 1Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases ...
Pu SD, Sun XT, Wang XC, Yu ZW, Shan ZY, Gao XY   +5 more
core  

Effects of thyroid-stimulating hormone and sensitivity to thyroid hormones on the risk of hyperuricemia in euthyroid adults

Archives of Endocrinology and Metabolism
The current study was conducted to investigate whether thyroid-stimulating hormone (TSH) and thyroid hormone sensitivity are associated with hyperuricemia probability in euthyroid population.The observational analysis was based on a Chinese community-based cohort (n = 1,972).
Ding, Hongzhan, Liang, Yanyu, Wang, Yilin, Zhang, Kexin, Zhu, Mengya, Jing, Yang, Xue, Yong, Chen, Xiaofang, Zhou, Hui, Dong, Chen   +9 more
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Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source