Association of impaired sensitivity to thyroid hormone with low bone mineral density and bone mineral content [PDF]
Frontiers in EndocrinologyOsteoporosis is a systemic condition characterized by reduced bone mineral density (BMD) and bone mineral content (BMC), with its global prevalence increasing annually.
Guoning Meng +7 more
doaj +2 more sources
Vitamin D Deficiency Is Associated with Impaired Sensitivity to Thyroid Hormones in Euthyroid Adults. [PDF]
Nutrients, 2023 The relationship between vitamin D deficiency and sensitivity to thyroid hormones was unclear. We aimed to explore the association of 25-hydroxyvitamin D (25(OH)D) levels with thyroid hormone sensitivity in euthyroid adults. A total of 3143 subjects were
Zhou L +5 more
europepmc +2 more sources
Reduced Sensitivity to Thyroid Hormone Is Associated with Diabetes and Hypertension [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2021 Abstract Context Recently, reduced sensitivity to thyroid hormone as a more common finding in the general population and its possible association with metabolic parameters has been the focus of attention.
Ladan Mehran +5 more
openaire +6 more sources
Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort
Frontiers in Endocrinology, 2023 PurposeThyroid hormones sensitivity is a newly proposed clinical entity closely related with metabolic health. Prior studies have reported the cross-sectional relationship between thyroid hormones sensitivity and diabetes; however, the longitudinal ...
Cancan Cui +8 more
doaj +1 more source
The syndromes of reduced sensitivity to thyroid hormone [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013 Six known steps are required for the circulating thyroid hormone (TH) to exert its action on target tissues. For three of these steps, human mutations and distinct phenotypes have been identified.The clinical, laboratory, genetic and molecular characteristics of these three defects of TH action are the subject of this review.
Alexandra M, Dumitrescu +1 more
openaire +2 more sources
Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD [PDF]
Frontiers in Endocrinology, 2021 BackgroundPrevious studies on the association between thyroid function and non‐alcoholic fatty liver disease (NAFLD) have contradicted. Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivity to thyroid hormone indices with NAFLD.MethodsA ...
Shuiqing Lai +5 more
openaire +3 more sources
Longitudinal evidence of the impact of normal thyroid stimulating hormone variations on cognitive functioning in very old age [PDF]
, 2008 The purpose of this study was to examine longitudinal associations among thyroid stimulating hormone (TSH) levels and cognitive performance. Data collected at the first three assessment times, approximately 3 years apart, are reported for the survivors ...
Wahlin, TBR, Wahlin, A, Bunce, D
core +6 more sources
Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor α [PDF]
Proceedings of the National Academy of Sciences, 2000 Only three of the four thyroid hormone receptor (TR) isoforms, α1, β1, and β2, bind thyroid hormone (TH) and are considered to be true TRs. TRα2 binds to TH response elements on DNA, but its role in vivo is still unknown. We produced mice completely deficient in TRα (TRα
Macchia, P.E. +11 more
openaire +6 more sources
Tissue sensitivity to thyroid hormones may change over time
European Thyroid Journal, 2023 Introduction: Patients with congenital hypothyroidism (CH) may transiently show a certain degree of pituitary resistance to levothyroxine (LT4) which, however, normalizes subsequently. However, in some individuals, thyroid-stimulating hormone (TSH) fails
Giorgio Radetti +9 more
doaj +1 more source
New Approaches to Thyroid Hormones and Purinergic Signaling [PDF]
, 2013 It is known that thyroid hormones influence a wide variety of events at the molecular, cellular, and functional levels. Thyroid hormones (TH) play pivotal roles in growth, cell proliferation, differentiation, apoptosis, development, and metabolic ...
Andréia Buffon +5 more
core +3 more sources